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Schema
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BlackBoxEvent
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Entries
Formation of the Spliceosomal Pre-B complex
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authored
[InstanceEdit:9769907] May, Bruce, 2022年03月22日
category
uncertain
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9770146] May, Bruce, 2022年03月24日
dbId
9770132
displayName
Formation of the Spliceosomal Pre-B complex
edited
[InstanceEdit:9769907] May, Bruce, 2022年03月22日
eventOf
[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-9770142] Formation of the Spliceosomal B complex - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-156649] ALYREF [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8849139] DDX39B [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770239] IK [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9769525] PRPF4B [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-6791189] SKIV2L2 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770259] SMU1 [nucleoplasm]
[Complex:R-HSA-9770140] Spliceosomal A complex [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-156781] SRRM1 [nucleoplasm]
[Complex:R-HSA-77506] U4:U5:U6 tri-snRNP complex [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9770241] A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity
[LiteratureReference:9769531] Mechanism of 5' splice site transfer for human spliceosome activation
[LiteratureReference:9769529] Structures of the human pre-catalytic spliceosome and its precursor spliceosome
[LiteratureReference:9769520] Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation
[LiteratureReference:9769583] Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes
[LiteratureReference:8850665] Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA
[LiteratureReference:927736] A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex
[LiteratureReference:9771906] Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles
[LiteratureReference:9818098] Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Formation of the Spliceosomal Pre-B complex
output
[EntityWithAccessionedSequence:R-HSA-72048] CCAR1 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-53703] DNAJC8 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770246] HTATSF1 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770253] PPP1R8 [nucleoplasm]
[Complex:R-HSA-9769528] Spliceosomal Pre-B complex [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-72043] SUGP1 [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-9770129] Formation of the Spliceosomal A complex - Homo sapiens
releaseDate
2022年12月07日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9818818] Charenton, Cl駑ent, 2022年10月20日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9770132
summation
[Summation:9770263] The U4/U6.U5 tri-snRNP complex loosely binds the Spliceosoma...
Referrals
(hasEvent)
[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway
(precedingEvent)
[BlackBoxEvent:R-HSA-9770142] Formation of the Spliceosomal B complex
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