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Schema
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Entries
Formation of the Spliceosomal C* complex
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authored
[InstanceEdit:9769907] May, Bruce, 2022年03月22日
catalystActivity
[CatalystActivity:9770421] RNA helicase activity of Spliceosomal C complex [nucleoplasm]
catalystActivityReference
[CatalystActivityReference:9643243] ATPase activity of Spliceosomal Intermediate C (Bact) Complex [nucleoplasm] Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing
category
uncertain
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9770146] May, Bruce, 2022年03月24日
dbId
9770141
deleted
[Deleted:9830332] Deletion of instance: 72139
displayName
Formation of the Spliceosomal C* complex
edited
[InstanceEdit:9769907] May, Bruce, 2022年03月22日
eventOf
[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-9770236] Formation of the Spliceosomal P complex and exon ligation - Homo sapiens
input
[SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9769591] CACTIN [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9769601] DDX41 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-5688092] DHX8 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9769598] FAM32A [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9769599] FAM50A [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-72073] hSLU7 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9769594] PRKRIP1 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-5688093] PRPF18 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9769593] SDE2 [nucleoplasm]
[Complex:R-HSA-9770138] Spliceosomal C complex [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9769596] STEEP1 [nucleoplasm]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:72132] Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
[LiteratureReference:72117] Large-scale proteomic analysis of the human spliceosome.
[LiteratureReference:6806800] Rearrangements within human spliceosomes captured after exon ligation
[LiteratureReference:9769583] Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes
[LiteratureReference:5566504] Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome
[LiteratureReference:9770783] An Atomic Structure of the Human Spliceosome
[LiteratureReference:9770792] Cryo-EM structure of a human spliceosome activated for step 2 of splicing
[LiteratureReference:9772739] Retinitis pigmentosa-linked mutation in DHX38 modulates its splicing activity
[LiteratureReference:9772746] Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing
[LiteratureReference:9772742] The mammalian homologue of Prp16p is overexpressed in a cell line tolerant to Leflunomide, a new immunoregulatory drug effective against rheumatoid arthritis
[LiteratureReference:9772729] A missense mutation in the splicing factor gene DHX38 is associated with early-onset retinitis pigmentosa with macular coloboma
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Formation of the Spliceosomal C* complex
Formation of the Active Spliceosomal C complex (update)
orthologousEvent
[BlackBoxEvent:R-MMU-9770141] Formation of the Spliceosomal C* complex - Mus musculus
[BlackBoxEvent:R-RNO-9770141] Formation of the Spliceosomal C* complex - Rattus norvegicus
[BlackBoxEvent:R-CFA-9770141] Formation of the Spliceosomal C* complex - Canis familiaris
[BlackBoxEvent:R-BTA-9770141] Formation of the Spliceosomal C* complex - Bos taurus
[BlackBoxEvent:R-SSC-9770141] Formation of the Spliceosomal C* complex - Sus scrofa
[BlackBoxEvent:R-DME-9770141] Formation of the Spliceosomal C* complex - Drosophila melanogaster
[BlackBoxEvent:R-CEL-9770141] Formation of the Spliceosomal C* complex - Caenorhabditis elegans
output
[SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8867898] CWC25 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770427] DHX35 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-72060] DHX38 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770419] GPATCH1 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770428] NSRP1 [nucleoplasm]
[SimpleEntity:R-ALL-113550] Pi [nucleoplasm]
[Complex:R-HSA-9770118] Spliceosomal C* complex [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770425] WDR70 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770430] YJU2 [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-9794542] Formation of the Spliceosomal C complex containing intron lariat - Homo sapiens
releaseDate
2022年12月07日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9818818] Charenton, Cl駑ent, 2022年10月20日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9770141
summation
[Summation:9771901] DHX38 (homolog of yeast Prp16) hydrolyzes ATP to remodel the...
Referrals
(precedingEvent)
[BlackBoxEvent:R-HSA-9770236] Formation of the Spliceosomal P complex and exon ligation
(hasEvent)
[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway
(replacementInstances)
[Deleted:9830332] Deletion of instance: 72139
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