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Schema
>
BlackBoxEvent
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Entries
Formation of the Spliceosomal B* complex
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authored
[InstanceEdit:9769907] May, Bruce, 2022年03月22日
catalystActivity
[CatalystActivity:9770423] RNA helicase activity of Spliceosomal Bact complex [nucleoplasm]
category
uncertain
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9770146] May, Bruce, 2022年03月24日
dbId
9770131
deleted
[Deleted:9830326] Deletion of instance: 156661
displayName
Formation of the Spliceosomal B* complex
edited
[InstanceEdit:9769907] May, Bruce, 2022年03月22日
eventOf
[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-9794542] Formation of the Spliceosomal C complex containing intron lariat - Homo sapiens
input
[SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8849148] CASC3 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8867898] CWC25 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770427] DHX35 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-72060] DHX38 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770419] GPATCH1 [nucleoplasm]
[Complex:R-HSA-156657] Magoh-Y14 complex [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770428] NSRP1 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9769592] PPIG [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8952113] PPIL4 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8867893] PPWD1 [nucleoplasm]
[Complex:R-HSA-9769560] Spliceosomal Bact complex [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8867884] SYF2 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-156776] UPF3B [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770425] WDR70 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770430] YJU2 [nucleoplasm]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:72132] Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
[LiteratureReference:72117] Large-scale proteomic analysis of the human spliceosome.
[LiteratureReference:5566504] Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome
[LiteratureReference:9769583] Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes
[LiteratureReference:157383] 5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly
[LiteratureReference:6806809] Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis
[LiteratureReference:9770574] Mass spectrometry-based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count
[LiteratureReference:9770594] Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method
[LiteratureReference:927736] A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex
[LiteratureReference:9772088] Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly
[LiteratureReference:8865939] CWC22 connects pre-mRNA splicing and exon junction complex assembly
[LiteratureReference:9772093] Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay
[LiteratureReference:9772613] Structure of a human catalytic step I spliceosome
[LiteratureReference:9770585] Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes
[LiteratureReference:8850870] Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Formation of the Spliceosomal B* complex
output
[SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8867885] CWC27 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8850837] DHX16 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8850839] GPKOW [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-2396419] MFAP1 [nucleoplasm]
[SimpleEntity:R-ALL-113550] Pi [nucleoplasm]
[Complex:R-HSA-9769523] RES complex [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9769563] RNF113A [nucleoplasm]
[Complex:R-HSA-71967] SF3A [nucleoplasm]
[Complex:R-HSA-71976] SF3B [nucleoplasm]
[Complex:R-HSA-9794539] Spliceosomal B* complex [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-9770145] Formation of the Spliceosomal Bact complex - Homo sapiens
releaseDate
2022年12月07日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9818818] Charenton, Cl駑ent, 2022年10月20日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9770131
summation
[Summation:9771078] DHX16 (homolog of yeast Prp2) hydrolyzes ATP in the Spliceos...
Referrals
(precedingEvent)
[BlackBoxEvent:R-HSA-9794542] Formation of the Spliceosomal C complex containing intron lariat
(hasEvent)
[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway
(replacementInstances)
[Deleted:9830326] Deletion of instance: 156661
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