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Schema
>
SimpleEntity
>
Entries
BH4 [cytosol]
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compartment
[Compartment:70101] cytosol
componentOf
[Complex:R-HSA-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] - Homo sapiens
[Complex:R-RNO-9860769] p-S1177,S1179-eNOS dimer [plasma membrane] - Rattus norvegicus
[Complex:R-RNO-9860769] p-S1177,S1179-eNOS dimer [plasma membrane] - Rattus norvegicus
[Complex:R-RNO-535006] palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] - Rattus norvegicus
[Complex:R-RNO-535006] palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] - Rattus norvegicus
[Complex:R-PFA-203808] palmitoylated, myristoylated eNOS dimer [Golgi membrane] - Plasmodium falciparum
[Complex:R-PFA-203808] palmitoylated, myristoylated eNOS dimer [Golgi membrane] - Plasmodium falciparum
consumedByEvent
[Reaction:R-HSA-1497866] Peroxynitrite can oxidise BH4 to the BH3 radical - Homo sapiens
[Reaction:R-HSA-1497824] BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle - Homo sapiens
[FailedReaction:R-HSA-5649483] Defective PAH does not hydroxylate L-Phe to L-Tyr - Homo sapiens
[Reaction:R-DDI-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Dictyostelium discoideum
[Reaction:R-CEL-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Caenorhabditis elegans
[Reaction:R-DME-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Drosophila melanogaster
[Reaction:R-GGA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Gallus gallus
[Reaction:R-XTR-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Xenopus tropicalis
[Reaction:R-DRE-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Danio rerio
[Reaction:R-SSC-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Sus scrofa
[Reaction:R-BTA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Bos taurus
[Reaction:R-CFA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Canis familiaris
[Reaction:R-RNO-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Rattus norvegicus
[Reaction:R-MMU-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Mus musculus
[Reaction:R-HSA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Homo sapiens
[Reaction:R-PFA-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Plasmodium falciparum
[Reaction:R-SCE-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Saccharomyces cerevisiae
[Reaction:R-SPO-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Schizosaccharomyces pombe
[Reaction:R-DDI-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Dictyostelium discoideum
[Reaction:R-CEL-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Caenorhabditis elegans
[Reaction:R-DME-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Drosophila melanogaster
[Reaction:R-GGA-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Gallus gallus
[Reaction:R-SSC-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Sus scrofa
[Reaction:R-BTA-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Bos taurus
[Reaction:R-RNO-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Rattus norvegicus
[Reaction:R-MMU-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Mus musculus
[Reaction:R-HSA-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Homo sapiens
[Reaction:R-DDI-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol - Dictyostelium discoideum
[Reaction:R-CEL-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol - Caenorhabditis elegans
[Reaction:R-GGA-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol - Gallus gallus
[Reaction:R-XTR-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol - Xenopus tropicalis
[Reaction:R-DRE-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol - Danio rerio
[Reaction:R-SSC-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol - Sus scrofa
[Reaction:R-BTA-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol - Bos taurus
[Reaction:R-CFA-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol - Canis familiaris
[Reaction:R-RNO-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol - Rattus norvegicus
[Reaction:R-MMU-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol - Mus musculus
[Reaction:R-HSA-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol - Homo sapiens
[Reaction:R-CEL-209823] Tyrosine is hydroxylated to dopa - Caenorhabditis elegans
[Reaction:R-DME-209823] Tyrosine is hydroxylated to dopa - Drosophila melanogaster
[Reaction:R-GGA-209823] Tyrosine is hydroxylated to dopa - Gallus gallus
[Reaction:R-XTR-209823] Tyrosine is hydroxylated to dopa - Xenopus tropicalis
[Reaction:R-DRE-209823] Tyrosine is hydroxylated to dopa - Danio rerio
[Reaction:R-SSC-209823] Tyrosine is hydroxylated to dopa - Sus scrofa
[Reaction:R-BTA-209823] Tyrosine is hydroxylated to dopa - Bos taurus
[Reaction:R-CFA-209823] Tyrosine is hydroxylated to dopa - Canis familiaris
[Reaction:R-RNO-209823] Tyrosine is hydroxylated to dopa - Rattus norvegicus
[Reaction:R-MMU-209823] Tyrosine is hydroxylated to dopa - Mus musculus
[Reaction:R-HSA-209823] Tyrosine is hydroxylated to dopa - Homo sapiens
[Reaction:R-DDI-209823] Tyrosine is hydroxylated to dopa - Dictyostelium discoideum
[Reaction:R-HSA-209828] Tryptophan is hydroxylated - Homo sapiens
[Reaction:R-MMU-209828] Tryptophan is hydroxylated - Mus musculus
[Reaction:R-RNO-209828] Tryptophan is hydroxylated - Rattus norvegicus
[Reaction:R-CFA-209828] Tryptophan is hydroxylated - Canis familiaris
[Reaction:R-BTA-209828] Tryptophan is hydroxylated - Bos taurus
[Reaction:R-SSC-209828] Tryptophan is hydroxylated - Sus scrofa
[Reaction:R-DRE-209828] Tryptophan is hydroxylated - Danio rerio
[Reaction:R-GGA-209828] Tryptophan is hydroxylated - Gallus gallus
[Reaction:R-DME-209828] Tryptophan is hydroxylated - Drosophila melanogaster
[Reaction:R-CEL-209828] Tryptophan is hydroxylated - Caenorhabditis elegans
[Reaction:R-DDI-209828] Tryptophan is hydroxylated - Dictyostelium discoideum
crossReference
[DatabaseIdentifier:29871] COMPOUND:C00272
dbId
29870
displayName
BH4 [cytosol]
inDisease
false
maxDepth
1
modified
[InstanceEdit:9929230] D'Eustachio, Peter, 2024年11月22日
name
BH4
sapropterin
Tetrahydrobiopterin
5,6,7,8-tetrahydrobiopterin
2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-pteridinone
negativelyRegulates
[NegativeRegulation:R-HSA-1474156] Negative regulation by 'BH4 [cytosol]'
producedByEvent
[Reaction:R-DDI-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Dictyostelium discoideum
[Reaction:R-CEL-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Caenorhabditis elegans
[Reaction:R-DME-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Drosophila melanogaster
[Reaction:R-GGA-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Gallus gallus
[Reaction:R-XTR-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Xenopus tropicalis
[Reaction:R-DRE-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Danio rerio
[Reaction:R-SSC-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Sus scrofa
[Reaction:R-BTA-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Bos taurus
[Reaction:R-CFA-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Canis familiaris
[Reaction:R-RNO-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Rattus norvegicus
[Reaction:R-MMU-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Mus musculus
[Reaction:R-HSA-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Homo sapiens
[Reaction:R-MMU-1497770] Salvage - BH2 is reduced to BH4 by Dhfr - Mus musculus
[Reaction:R-HSA-1497794] Salvage - BH2 is reduced to BH4 by DHFR - Homo sapiens
[Reaction:R-HSA-1497855] Ascorbate can reduce the BH3 radical back to BH4 - Homo sapiens
[Reaction:R-DDI-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Dictyostelium discoideum
[Reaction:R-DME-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Drosophila melanogaster
[Reaction:R-GGA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Gallus gallus
[Reaction:R-XTR-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Xenopus tropicalis
[Reaction:R-HSA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Homo sapiens
[Reaction:R-HSA-1497883] Ferrous iron reduces the BH3 radical back to BH4 - Homo sapiens
[Reaction:R-MMU-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Mus musculus
[Reaction:R-RNO-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Rattus norvegicus
[Reaction:R-CFA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Canis familiaris
[Reaction:R-BTA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Bos taurus
[Reaction:R-SSC-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Sus scrofa
[Reaction:R-DRE-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Danio rerio
[Reaction:R-PFA-1497796] BH2 binding can lead to eNOS uncoupling - Plasmodium falciparum
[Reaction:R-SCE-1497796] BH2 binding can lead to eNOS uncoupling - Saccharomyces cerevisiae
[Reaction:R-SPO-1497796] BH2 binding can lead to eNOS uncoupling - Schizosaccharomyces pombe
[Reaction:R-DDI-1497796] BH2 binding can lead to eNOS uncoupling - Dictyostelium discoideum
[Reaction:R-CEL-1497796] BH2 binding can lead to eNOS uncoupling - Caenorhabditis elegans
[Reaction:R-DME-1497796] BH2 binding can lead to eNOS uncoupling - Drosophila melanogaster
[Reaction:R-GGA-1497796] BH2 binding can lead to eNOS uncoupling - Gallus gallus
[Reaction:R-SSC-1497796] BH2 binding can lead to eNOS uncoupling - Sus scrofa
[Reaction:R-BTA-1497796] BH2 binding can lead to eNOS uncoupling - Bos taurus
[Reaction:R-RNO-1497796] BH2 binding can lead to eNOS uncoupling - Rattus norvegicus
[Reaction:R-MMU-1497796] BH2 binding can lead to eNOS uncoupling - Mus musculus
[Reaction:R-HSA-1497796] BH2 binding can lead to eNOS uncoupling - Homo sapiens
referenceEntity
[ReferenceMolecule:chebi:59560] sapropterin [ChEBI:59560]
referenceType
ReferenceMolecule
schemaClass
SimpleEntity
stId
R-ALL-29870
updateTrackers
[UpdateTracker:9891310] Update Tracker - [SimpleEntity:29870] BH4 [cytosol] - v52:[modifyName]
[UpdateTracker:9940007] Update Tracker - [SimpleEntity:29870] BH4 [cytosol] - v92:[add_removeReferenceEntity, removeName]
[UpdateTracker:9870396] Update Tracker - [SimpleEntity:29870] BH4 [cytosol] - v38:[addName]
Referrals
(hasComponent)
[Complex:R-RNO-9860769] p-S1177,S1179-eNOS dimer [plasma membrane]
[Complex:R-PFA-9860769] p-S1177,S1179-eNOS dimer [plasma membrane]
[Complex:R-SCE-9860769] p-S1177,S1179-eNOS dimer [plasma membrane]
[Complex:R-MMU-9860769] p-S1177,S1179-eNOS dimer [plasma membrane]
[Complex:R-SPO-9860769] p-S1177,S1179-eNOS dimer [plasma membrane]
[Complex:R-GGA-9860769] p-S1177,S1179-eNOS dimer [plasma membrane]
[Complex:R-DME-9860769] p-S1177,S1179-eNOS dimer [plasma membrane]
[Complex:R-DDI-9860769] p-S1177,S1179-eNOS dimer [plasma membrane]
[Complex:R-BTA-9860769] p-S1177,S1179-eNOS dimer [plasma membrane]
[Complex:R-SSC-9860769] p-S1177,S1179-eNOS dimer [plasma membrane]
[Complex:R-HSA-9860769] p-S1177,S1179-eNOS dimer [plasma membrane]
[Complex:R-DME-9861320] p-S633-eNOS dimer [plasma membrane]
[Complex:R-DDI-9861320] p-S633-eNOS dimer [plasma membrane]
[Complex:R-SSC-9861320] p-S633-eNOS dimer [plasma membrane]
[Complex:R-RNO-9861320] p-S633-eNOS dimer [plasma membrane]
[Complex:R-MMU-9861320] p-S633-eNOS dimer [plasma membrane]
[Complex:R-BTA-9861320] p-S633-eNOS dimer [plasma membrane]
[Complex:R-SCE-9861320] p-S633-eNOS dimer [plasma membrane]
[Complex:R-SPO-9861320] p-S633-eNOS dimer [plasma membrane]
[Complex:R-PFA-9861320] p-S633-eNOS dimer [plasma membrane]
[Complex:R-GGA-9861320] p-S633-eNOS dimer [plasma membrane]
[Complex:R-HSA-9861320] p-S633-eNOS dimer [plasma membrane]
[Complex:R-PFA-203808] palmitoylated, myristoylated eNOS dimer [Golgi membrane]
[Complex:R-RNO-203808] palmitoylated, myristoylated eNOS dimer [Golgi membrane]
[Complex:R-SSC-203808] palmitoylated, myristoylated eNOS dimer [Golgi membrane]
[Complex:R-DDI-203808] palmitoylated, myristoylated eNOS dimer [Golgi membrane]
[Complex:R-BTA-203808] palmitoylated, myristoylated eNOS dimer [Golgi membrane]
[Complex:R-MMU-203808] palmitoylated, myristoylated eNOS dimer [Golgi membrane]
[Complex:R-DME-203808] palmitoylated, myristoylated eNOS dimer [Golgi membrane]
[Complex:R-HSA-203808] palmitoylated, myristoylated eNOS dimer [Golgi membrane]
[Complex:R-RNO-535006] palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane]
[Complex:R-SSC-535006] palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane]
[Complex:R-BTA-535006] palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane]
[Complex:R-GGA-535006] palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane]
[Complex:R-MMU-535006] palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane]
[Complex:R-DRE-535006] palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane]
[Complex:R-HSA-535006] palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane]
[Complex:R-CFA-535006] palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane]
[Complex:R-PFA-203969] myristoylated eNOS dimer [Golgi membrane]
[Complex:R-SSC-203969] myristoylated eNOS dimer [Golgi membrane]
[Complex:R-RNO-203969] myristoylated eNOS dimer [Golgi membrane]
[Complex:R-DME-203969] myristoylated eNOS dimer [Golgi membrane]
[Complex:R-SPO-203969] myristoylated eNOS dimer [Golgi membrane]
[Complex:R-SCE-203969] myristoylated eNOS dimer [Golgi membrane]
[Complex:R-DDI-203969] myristoylated eNOS dimer [Golgi membrane]
[Complex:R-BTA-203969] myristoylated eNOS dimer [Golgi membrane]
[Complex:R-GGA-203969] myristoylated eNOS dimer [Golgi membrane]
[Complex:R-MMU-203969] myristoylated eNOS dimer [Golgi membrane]
[Complex:R-HSA-203969] myristoylated eNOS dimer [Golgi membrane]
[Complex:R-SPO-203619] myristoylated eNOS dimer [cytosol]
[Complex:R-MMU-203619] myristoylated eNOS dimer [cytosol]
[Complex:R-DDI-203619] myristoylated eNOS dimer [cytosol]
[Complex:R-PFA-203619] myristoylated eNOS dimer [cytosol]
[Complex:R-BTA-203619] myristoylated eNOS dimer [cytosol]
[Complex:R-RNO-203619] myristoylated eNOS dimer [cytosol]
[Complex:R-SCE-203619] myristoylated eNOS dimer [cytosol]
[Complex:R-SSC-203619] myristoylated eNOS dimer [cytosol]
[Complex:R-DME-203619] myristoylated eNOS dimer [cytosol]
[Complex:R-GGA-203619] myristoylated eNOS dimer [cytosol]
[Complex:R-HSA-203619] myristoylated eNOS dimer [cytosol]
[Complex:R-HSA-203564] p-S1177-eNOS dimer [plasma membrane]
[Complex:R-DME-203564] p-S1177-eNOS dimer [plasma membrane]
[Complex:R-CEL-203564] p-S1177-eNOS dimer [plasma membrane]
[Complex:R-SSC-203564] p-S1177-eNOS dimer [plasma membrane]
[Complex:R-RNO-203564] p-S1177-eNOS dimer [plasma membrane]
[Complex:R-SCE-203564] p-S1177-eNOS dimer [plasma membrane]
[Complex:R-MMU-203564] p-S1177-eNOS dimer [plasma membrane]
[Complex:R-BTA-203564] p-S1177-eNOS dimer [plasma membrane]
[Complex:R-DDI-203564] p-S1177-eNOS dimer [plasma membrane]
[Complex:R-GGA-203564] p-S1177-eNOS dimer [plasma membrane]
[Complex:R-PFA-203564] p-S1177-eNOS dimer [plasma membrane]
[Complex:R-SPO-203564] p-S1177-eNOS dimer [plasma membrane]
[Complex:R-HSA-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
[Complex:R-MMU-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
[Complex:R-DDI-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
[Complex:R-PFA-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
[Complex:R-GGA-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
[Complex:R-BTA-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
[Complex:R-SPO-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
[Complex:R-DME-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
[Complex:R-RNO-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
[Complex:R-SSC-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
[Complex:R-CEL-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
[Complex:R-SCE-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
(input)
[Reaction:R-DDI-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol
[Reaction:R-CEL-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol
[Reaction:R-GGA-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol
[Reaction:R-XTR-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol
[Reaction:R-DRE-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol
[Reaction:R-SSC-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol
[Reaction:R-BTA-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol
[Reaction:R-CFA-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol
[Reaction:R-RNO-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol
[Reaction:R-MMU-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol
[Reaction:R-HSA-5696119] AGMO cleaves alkylglycerol into fatty aldehyde and glycerol
[FailedReaction:R-HSA-5649483] Defective PAH does not hydroxylate L-Phe to L-Tyr
[Reaction:R-CEL-209823] Tyrosine is hydroxylated to dopa
[Reaction:R-DME-209823] Tyrosine is hydroxylated to dopa
[Reaction:R-GGA-209823] Tyrosine is hydroxylated to dopa
[Reaction:R-XTR-209823] Tyrosine is hydroxylated to dopa
[Reaction:R-DRE-209823] Tyrosine is hydroxylated to dopa
[Reaction:R-SSC-209823] Tyrosine is hydroxylated to dopa
[Reaction:R-BTA-209823] Tyrosine is hydroxylated to dopa
[Reaction:R-CFA-209823] Tyrosine is hydroxylated to dopa
[Reaction:R-RNO-209823] Tyrosine is hydroxylated to dopa
[Reaction:R-MMU-209823] Tyrosine is hydroxylated to dopa
[Reaction:R-HSA-209823] Tyrosine is hydroxylated to dopa
[Reaction:R-DDI-209823] Tyrosine is hydroxylated to dopa
[Reaction:R-DDI-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
[Reaction:R-CEL-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
[Reaction:R-DME-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
[Reaction:R-GGA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
[Reaction:R-XTR-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
[Reaction:R-DRE-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
[Reaction:R-SSC-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
[Reaction:R-BTA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
[Reaction:R-CFA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
[Reaction:R-RNO-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
[Reaction:R-MMU-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
[Reaction:R-HSA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
[Reaction:R-HSA-1497866] Peroxynitrite can oxidise BH4 to the BH3 radical
[Reaction:R-PFA-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
[Reaction:R-SCE-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
[Reaction:R-SPO-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
[Reaction:R-DDI-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
[Reaction:R-CEL-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
[Reaction:R-DME-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
[Reaction:R-GGA-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
[Reaction:R-SSC-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
[Reaction:R-BTA-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
[Reaction:R-RNO-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
[Reaction:R-MMU-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
[Reaction:R-HSA-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
[Reaction:R-HSA-209828] Tryptophan is hydroxylated
[Reaction:R-MMU-209828] Tryptophan is hydroxylated
[Reaction:R-RNO-209828] Tryptophan is hydroxylated
[Reaction:R-CFA-209828] Tryptophan is hydroxylated
[Reaction:R-BTA-209828] Tryptophan is hydroxylated
[Reaction:R-SSC-209828] Tryptophan is hydroxylated
[Reaction:R-DRE-209828] Tryptophan is hydroxylated
[Reaction:R-GGA-209828] Tryptophan is hydroxylated
[Reaction:R-DME-209828] Tryptophan is hydroxylated
[Reaction:R-CEL-209828] Tryptophan is hydroxylated
[Reaction:R-DDI-209828] Tryptophan is hydroxylated
[Reaction:R-HSA-1497824] BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle
(output)
[Reaction:R-DDI-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
[Reaction:R-CEL-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
[Reaction:R-DME-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
[Reaction:R-GGA-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
[Reaction:R-XTR-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
[Reaction:R-DRE-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
[Reaction:R-SSC-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
[Reaction:R-BTA-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
[Reaction:R-CFA-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
[Reaction:R-RNO-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
[Reaction:R-MMU-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
[Reaction:R-HSA-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
[Reaction:R-MMU-1497770] Salvage - BH2 is reduced to BH4 by Dhfr
[Reaction:R-HSA-1497794] Salvage - BH2 is reduced to BH4 by DHFR
[Reaction:R-PFA-1497796] BH2 binding can lead to eNOS uncoupling
[Reaction:R-SCE-1497796] BH2 binding can lead to eNOS uncoupling
[Reaction:R-SPO-1497796] BH2 binding can lead to eNOS uncoupling
[Reaction:R-DDI-1497796] BH2 binding can lead to eNOS uncoupling
[Reaction:R-CEL-1497796] BH2 binding can lead to eNOS uncoupling
[Reaction:R-DME-1497796] BH2 binding can lead to eNOS uncoupling
[Reaction:R-GGA-1497796] BH2 binding can lead to eNOS uncoupling
[Reaction:R-SSC-1497796] BH2 binding can lead to eNOS uncoupling
[Reaction:R-BTA-1497796] BH2 binding can lead to eNOS uncoupling
[Reaction:R-RNO-1497796] BH2 binding can lead to eNOS uncoupling
[Reaction:R-MMU-1497796] BH2 binding can lead to eNOS uncoupling
[Reaction:R-HSA-1497855] Ascorbate can reduce the BH3 radical back to BH4
[Reaction:R-DDI-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR)
[Reaction:R-DME-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR)
[Reaction:R-GGA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR)
[Reaction:R-XTR-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR)
[Reaction:R-HSA-1497796] BH2 binding can lead to eNOS uncoupling
[Reaction:R-HSA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR)
[Reaction:R-HSA-1497883] Ferrous iron reduces the BH3 radical back to BH4
[Reaction:R-MMU-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR)
[Reaction:R-RNO-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR)
[Reaction:R-CFA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR)
[Reaction:R-BTA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR)
[Reaction:R-SSC-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR)
[Reaction:R-DRE-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR)
(regulator)
[NegativeRegulation:R-HSA-1474156] Negative regulation by 'BH4 [cytosol]'
(updatedInstance)
[UpdateTracker:9891310] Update Tracker - [SimpleEntity:29870] BH4 [cytosol] - v52:[modifyName]
[UpdateTracker:9940007] Update Tracker - [SimpleEntity:29870] BH4 [cytosol] - v92:[add_removeReferenceEntity, removeName]
[UpdateTracker:9870396] Update Tracker - [SimpleEntity:29870] BH4 [cytosol] - v38:[addName]
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