Reactome Pathway Database

Schema > Reaction > Entries

The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle Show undefined attributes

catalystActivity

[CatalystActivity:10721742] tetrahydrobiopterin binding activity of p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane]

category transition

compartment

created [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

dbId 10721744

displayName The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle

eventOf

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-GGA-202127] eNOS synthesizes NO - Gallus gallus

inferredFrom

[Reaction:R-HSA-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle

output

[Complex:R-GGA-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]

precedingEvent

[Reaction:R-GGA-202111] AKT1 phosphorylates eNOS - Gallus gallus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49591] Gallus gallus

stId R-GGA-1497784

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

(precedingEvent)

[Reaction:R-GGA-202127] eNOS synthesizes NO

(inferredTo)

[Reaction:R-HSA-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle

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