PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr

authored
catalystActivity
catalystActivityReference [CatalystActivityReference:9643292] phenylalanine 4-monooxygenase activity of PAH:Fe2+ tetramer [cytosol] Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria
category transition
compartment
crossReference
dbId 71118
displayName PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
edited
eventOf
followingEvent
input
isInDisease false
isInferred false
literatureReference
maxDepth 1
modified [InstanceEdit:10948619] Weiser, Joel, 2025年08月27日
name
  • PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
  • (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  • phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O
orthologousEvent
output
precedingEvent
releaseDate 2004年07月06日
reviewStatus [ReviewStatus:9821382] five stars
schemaClass Reaction
species
stId R-HSA-71118
summation
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