Reactome Pathway Database

Schema > Reaction > Entries

Tryptophan is hydroxylated Show undefined attributes

catalystActivity

[CatalystActivity:10882982] tryptophan 5-monooxygenase activity of TPH:Fe++ [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

dbId 10882984

displayName Tryptophan is hydroxylated

eventOf

[Pathway:R-CEL-209931] Serotonin and melatonin biosynthesis - Caenorhabditis elegans

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-CEL-209859] Decarboxylation of 5-hydroxytryptophan forms serotonin - Caenorhabditis elegans

inferredFrom

[Reaction:R-HSA-209828] Tryptophan is hydroxylated - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

Tryptophan is hydroxylated

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:68320] Caenorhabditis elegans

stId R-CEL-209828

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-CEL-209931] Serotonin and melatonin biosynthesis

(precedingEvent)

[Reaction:R-CEL-209859] Decarboxylation of 5-hydroxytryptophan forms serotonin

(inferredTo)

[Reaction:R-HSA-209828] Tryptophan is hydroxylated

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