InnateDB: Systems Biology of the Innate Immune Response

Version 5.4
Homo sapiens Gene: ACE
Summary
InnateDB Gene IDBG-63266.6
Last Modified 2014年10月13日 [Report errors or provide feedback]
Gene Symbol ACE
Gene Name angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Synonyms ACE1; CD143; DCP; DCP1; ICH; MVCD3
Species Homo sapiens
Ensembl Gene ENSG00000159640
Encoded Proteins
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Ace and iNOS overexpression by myelomonocytic cells substantially boosts innate immunity and represents a new means to address serious bacterial infections such as L. monocytogenes and methicillin resistant S. Aureus.
Entrez Gene
Summary This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:63477061-63498380
Strand Forward strand
Band q23.3
Transcripts
ENST00000290866 ENSP00000290866
ENST00000290863 ENSP00000290863
ENST00000413513 ENSP00000392247
ENST00000428043 ENSP00000397593
ENST00000421982 ENSP00000387760
ENST00000582627 ENSP00000462280
ENST00000579409 ENSP00000464428
ENST00000577418
ENST00000582678 ENSP00000462995
ENST00000584865
ENST00000579462
ENST00000580318 ENSP00000463302
ENST00000582761 ENSP00000462909
ENST00000579204 ENSP00000464629
ENST00000582244
ENST00000583336
ENST00000578679
ENST00000578839 ENSP00000462110
ENST00000584529
ENST00000579314 ENSP00000462599
ENST00000583645
ENST00000579726 ENSP00000463673
ENST00000582005 ENSP00000462002
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19
Protein-DNA 1
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology
Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004175 endopeptidase activity
GO:0004180 carboxypeptidase activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
GO:0008270 zinc ion binding
GO:0031404 chloride ion binding
GO:0031711 bradykinin receptor binding
Biological Process
GO:0001822 kidney development
GO:0001974 blood vessel remodeling
GO:0002003 angiotensin maturation
GO:0002005 angiotensin catabolic process in blood
GO:0002019 regulation of renal output by angiotensin
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
GO:0006508 proteolysis
GO:0008217 regulation of blood pressure
GO:0014910 regulation of smooth muscle cell migration
GO:0019229 regulation of vasoconstriction
GO:0032943 mononuclear cell proliferation
GO:0042312 regulation of vasodilation
GO:0042447 hormone catabolic process
GO:0043171 peptide catabolic process
GO:0044267 cellular protein metabolic process
GO:0050482 arachidonic acid secretion
GO:0060218 hematopoietic stem cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways NETPATH REACTOME
Metabolism of Angiotensinogen to Angiotensins pathway
Metabolism of proteins pathway
Peptide hormone metabolism pathway
KEGG
Renin-angiotensin system pathway
Hypertrophic cardiomyopathy (HCM) pathway
Chagas disease (American trypanosomiasis) pathway
INOH PID NCI Cross-References SwissProt TrEMBL UniProt Splice Variant Entrez Gene UniGene Hs.712079 RefSeq NM_000789 NM_001178057 NM_152830 HUGO OMIM CCDS CCDS11637 CCDS45755 CCDS54155 HPRD 00108 IMGT EMBL GenPept RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca

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