InnateDB: Systems Biology of the Innate Immune Response

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Homo sapiens Protein: ACE
Summary
InnateDB Protein	IDBP-63270.7
Last Modified	2014年10月13日 [Report errors or provide feedback]
Gene Symbol	ACE
Protein Name	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Synonyms	ACE1; CD143; DCP; DCP1; ICH; MVCD3;
Species	Homo sapiens
Ensembl Protein	ENSP00000290863
InnateDB Gene	IDBG-63266 (ACE)
Protein Structure
UniProt Annotation
Function	Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Subcellular Localization	Angiotensin-converting enzyme, soluble form: Secreted.Cell membrane; Single-pass type I membrane protein. Cytoplasm {ECO:0000250}. Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000250}.
Disease Associations	Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269PubMed:15534175}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269PubMed:16116425}. Note=The disease is caused by mutations affecting the gene represented in this entry.Microvascular complications of diabetes 3 (MVCD3) [MIM:612624]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end- stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Intracerebral hemorrhage (ICH) [MIM:614519]: A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. {ECO:0000269PubMed:15277638}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Tissue Specificity	Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis. {ECO:0000269PubMed:10924499, ECO:0000269PubMed:10969042, ECO:0000269PubMed:12459472, ECO:0000269PubMed:15671045}.
Comments
Interactions
Number of Interactions	This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database. Experimentally validated Total 20 [view] Protein-Protein 19 Protein-DNA 1 Protein-RNA 0 DNA-DNA 0 RNA-RNA 0 DNA-RNA 0

Gene Ontology
Molecular Function

Accession GO Term

GO:0003779 actin binding

GO:0004175 endopeptidase activity

GO:0004180 carboxypeptidase activity

GO:0005515 protein binding

GO:0008144 drug binding

GO:0008237 metallopeptidase activity

GO:0008241 peptidyl-dipeptidase activity

GO:0008270 zinc ion binding

GO:0031404 chloride ion binding

GO:0031711 bradykinin receptor binding

Biological Process

GO:0001822 kidney development

GO:0001974 blood vessel remodeling

GO:0002003 angiotensin maturation

GO:0002005 angiotensin catabolic process in blood

GO:0002019 regulation of renal output by angiotensin

GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin

GO:0006508 proteolysis

GO:0008217 regulation of blood pressure

GO:0014910 regulation of smooth muscle cell migration

GO:0019229 regulation of vasoconstriction

GO:0032943 mononuclear cell proliferation

GO:0042312 regulation of vasodilation

GO:0042447 hormone catabolic process

GO:0043171 peptide catabolic process

GO:0044267 cellular protein metabolic process

GO:0050482 arachidonic acid secretion

GO:0060218 hematopoietic stem cell differentiation

Cellular Component

GO:0005576 extracellular region

GO:0005615 extracellular space

GO:0005768 endosome

GO:0005886 plasma membrane

GO:0009897 external side of plasma membrane

GO:0016020 membrane

GO:0016021 integral component of membrane

GO:0070062 extracellular vesicular exosome

Protein Structure and Domains PDB ID InterPro IPR001548 Peptidase M2, peptidyl-dipeptidase A
PFAM PF01401
PRINTS PR00791
PIRSF SMART TIGRFAMs Post-translational Modifications Modification Cross-References SwissProt P12821 PhosphoSite PhosphoSite-P12821 TrEMBL Q3KRI5 UniProt Splice Variant Entrez Gene 1636 UniGene Hs.712079 RefSeq NP_690043 HUGO HGNC:2707 OMIM 106180 CCDS CCDS45755 HPRD 00108 IMGT EMBL AB208971 AC113554 AF118569 AK301988 AY436326 AY999972 AY999973 CH471109 EU332840 J04144 M26657 X16295 GenPept AAA51684 AAA60611 AAD28560 AAR03504 ABA39228 ABA39229 ABY87529 BAD92208 BAG63395 CAA34362 EAW94319 EAW94321

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca