| Bos taurus Gene: ACE | |
|---|---|
| Summary | |
| InnateDB Gene | IDBG-641515.3 |
| Last Modified | 2014年10月13日 [Report errors or provide feedback] |
| Gene Symbol | ACE |
| Gene Name | angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 precursor |
| Synonyms | |
| Species | Bos taurus |
| Ensembl Gene | ENSBTAG00000024950 |
| Encoded Proteins |
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
|
| Protein Structure | |
| Useful resources | Stemformatics EHFPI ImmGen |
| InnateDB Annotation from Orthologs | |
| Summary |
[Mus musculus] Ace and iNOS overexpression by myelomonocytic cells substantially boosts innate immunity and represents a new means to address serious bacterial infections such as L. monocytogenes and methicillin resistant S. Aureus.
|
| Entrez Gene | |
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159640:
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010] |
| Gene Information | |
| Type | Protein coding |
| Genomic Location | Chromosome 19:48447902-48467904 |
| Strand | Forward strand |
| Band | |
| Transcripts | |
| Interactions | |
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology. Predicted by orthology
Total
1 [view]
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InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).
Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca