KCNH3

Protein-coding gene in humans

KCNH3

Identifiers

KCNH3 , BEC1, ELK2, Kv12.2, potassium voltage-gated channel subfamily H member 3

External IDs

OMIM: 604527; MGI: 1341723; HomoloGene: 32150; GeneCards: KCNH3; OMA:KCNH3 - orthologs

Gene location (Human)
Chromosome 12 (human)
Chr.	Chromosome 12 (human) ^[1]
Chromosome 12 (human) Genomic location for KCNH3 Genomic location for KCNH3
Band	12q13.12	Start	49,539,030 bp ^[1]
Band	12q13.12	End	49,558,337 bp ^[1]

Gene location (Mouse)
Chromosome 15 (mouse)
Chr.	Chromosome 15 (mouse)^[2]
Chromosome 15 (mouse) Genomic location for KCNH3 Genomic location for KCNH3
Band	15\|15 F1	Start	99,122,742 bp ^[2]
Band	15\|15 F1	End	99,140,698 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in right frontal lobe Brodmann area 9 cingulate gyrus anterior cingulate cortex prefrontal cortex amygdala caudate nucleus putamen right uterine tube nucleus accumbens	Top expressed in superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell prefrontal cortex Region I of hippocampus proper olfactory tubercle subiculum piriform cortex gastrula ciliary body
More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	phosphorelay sensor kinase activity protein binding voltage-gated potassium channel activity ion channel activity potassium channel activity voltage-gated ion channel activity
Cellular component	intracellular anatomical structure plasma membrane integral component of membrane membrane integral component of plasma membrane
Biological process	phosphorelay signal transduction system signal transduction regulation of ion transmembrane transport regulation of membrane potential potassium ion transmembrane transport potassium ion transport ion transport transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23416


16512

Ensembl


ENSG00000135519


ENSMUSG00000037579

UniProt


Q9ULD8


Q9WVJ0

RefSeq (mRNA)

NM_001314030
NM_012284

NM_010601

RefSeq (protein)

NP_001300959
NP_036416

NP_034731

Location (UCSC)

Chr 12: 49.54 – 49.56 Mb

Chr 15: 99.12 – 99.14 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily H member 3 is a protein that in humans is encoded by the KCNH3 gene.^[5]^[6] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[5]^[6]

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135519 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037579 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Miyake A, Mochizuki S, Yokoi H, Kohda M, Furuichi K (Sep 1999). "New ether-a-go-go K(+) channel family members localized in human telencephalon". J Biol Chem. 274 (35): 25018–25. doi:10.1074/jbc.274.35.25018 . PMID 10455180.
^ ^a ^b Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

External links

[edit ]

Kv12.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNH3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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References

Further reading

External links