KCNA7

Protein-coding gene in the species Homo sapiens

KCNA7

Identifiers

KCNA7 , HAK6, KV1.7, potassium voltage-gated channel subfamily A member 7

External IDs

OMIM: 176268; MGI: 96664; HomoloGene: 7791; GeneCards: KCNA7; OMA:KCNA7 - orthologs

Gene location (Human)
Chromosome 19 (human)
Chr.	Chromosome 19 (human) ^[1]
Chromosome 19 (human) Genomic location for KCNA7 Genomic location for KCNA7
Band	19q13.33	Start	49,067,397 bp ^[1]
Band	19q13.33	End	49,072,699 bp ^[1]

Gene location (Mouse)
Chromosome 7 (mouse)
Chr.	Chromosome 7 (mouse)^[2]
Chromosome 7 (mouse) Genomic location for KCNA7 Genomic location for KCNA7
Band	7 B3\|7 29.3 cM	Start	45,055,077 bp ^[2]
Band	7 B3\|7 29.3 cM	End	45,059,187 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in Skeletal muscle tissue of rectus abdominis vastus lateralis muscle muscle of thigh Skeletal muscle tissue of biceps brachii gastrocnemius muscle deltoid muscle tibialis anterior muscle body of tongue apex of heart right auricle of heart	Top expressed in muscle of thigh skeletal muscle tissue quadriceps femoris muscle zone of skin lip esophagus embryo heart spermatocyte placenta
More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	ion channel activity potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity
Cellular component	integral component of membrane voltage-gated potassium channel complex plasma membrane membrane
Biological process	potassium ion transport regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3743


16495

Ensembl


ENSG00000104848


ENSMUSG00000038201

UniProt


Q96RP8


Q17ST2

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19: 49.07 – 49.07 Mb

Chr 7: 45.06 – 45.06 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily A member 7 also known as K_v1.7 is a protein that in humans is encoded by the KCNA7 gene.^[5] The protein encoded by this gene is a voltage-gated potassium channel subunit. It may contribute to the cardiac transient outward potassium current (I_to1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.^[6]

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104848 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038201 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". J. Mol. Cell. Cardiol. 33 (5): 851–72. doi:10.1006/jmcc.2001.1376. PMID 11343410.

External links

[edit ]

Kv1.7+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNA7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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References

Further reading

External links