| Accession: | |
|---|---|
| Functional site class: | HCF-1 binding motif |
| Functional site description: | The Host Cell Factor-1 (HCF-1) is a transcriptional co-activator involved in a number of important gene regulatory complexes. HCF-1 is a chromatin associated protein and it interacts with a wide variety of cellular factors including co-activators and co-repressors that function in cell growth and cell division. It is conserved from human to nematodes. HCF-1 contains several domains that mediate specific interaction with different binding partners. In particular the N-terminal region contains six kelch repeats that fold into a six-bladed propeller domain. This propeller region is sufficient to target a number of interacting proteins by recognizing a conserved DHxY peptide sequence known as the HCF-1 binding motif (HBM). |
| ELM Description: | The HBM is a short well-conserved sequence motif matching [ED]HxY. (A reported exception is an NHNY in BAP1 but, as this is an isolated outlier, it has not been included in the current ELM regular expression.) The motif is typically found in transcriptional regulators that affect cell cycle. HBM belongs to the common category of beta propeller-binding motifs. Although there is not yet a solved structure for the HBM in complex with the kelch repeat propeller, the evidence for the interaction is strong and the motif description appears convincing, based on strong motif conservation in multiple protein families. |
| Pattern: | [DE]H.Y |
| Pattern Probability: | 0.0000507 |
| Present in taxon: | Metazoa |
| Interaction Domain: |
Kelch_3 (PF13415)
Galactose oxidase, central domain
(Stochiometry: 4 : 1)
|