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Lazabemide

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Lazabemide
Clinical data
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • Development terminated
Identifiers
  • N-(2-aminoethyl)-5-chloro-pyridine-2-carboxamide
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
Formula C8H10ClN3O
Molar mass 199.64 g·mol−1

Lazabemide (proposed trade names Pakio, Tempium) is a reversible and selective inhibitor of monoamine oxidase B (MAO-B) that was under development as an antiparkinsonian agent but was never marketed.[1]

References

[edit ]
  1. ^ Henriot S, Kuhn C, Kettler R, Da Prada M (1994). "Lazabemide (Ro 19-6327), a reversible and highly sensitive MAO-B inhibitor: Preclinical and clinical findings". In Tipton KF, Youdim MB, Barwell CJ, Callingham BA, Lyles GA (eds.). Amine Oxidases: Function and Dysfunction. Proceedings of the 5th International Amine Oxidase Workshop, Galway, Ireland, August 22–25, 1992. Journal of Neural Transmission. Supplementum. Vol. 41. pp. 321–325. doi:10.1007/978-3-7091-9324-2_42. ISBN 978-3-211-82521-1. PMID 7931245.
Dopaminergics
DA precursors
DA receptor agonists
MAO-B inhibitors
COMT inhibitors
AAAD inhibitors
Anticholinergics
Others
Non-specific
AAAD Tooltip Aromatic L-amino acid decarboxylase
MAO Tooltip Monoamine oxidase
Phenethylamines
(dopamine, epinephrine,
norepinephrine)
PAH Tooltip Phenylalanine hydroxylase
TH Tooltip Tyrosine hydroxylase
DBH Tooltip Dopamine beta-hydroxylase
PNMT Tooltip Phenylethanolamine N-methyltransferase
COMT Tooltip Catechol-O-methyl transferase
Tryptamines
(serotonin, melatonin)
TPH Tooltip Tryptophan hydroxylase
AANAT Tooltip Serotonin N-acetyl transferase
ASMT Tooltip Acetylserotonin O-methyltransferase
Histamine
HDC Tooltip Histidine decarboxylase
HNMT Tooltip Histamine N-methyltransferase
DAO Tooltip Diamine oxidase


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