Eprobemide
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Chemical compound
Pharmaceutical compound
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| Trade names | Befol (RU) |
| Other names | Befol |
| Routes of administration | Oral |
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| Chemical and physical data | |
| Formula | C14H19ClN2O2 |
| Molar mass | 282.77 g·mol−1 |
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Eprobemide (INN) is a pharmaceutical drug that was used as an antidepressant in Russia (under the brand name Бефол/Befol).[1] It is a non-competitive reversible inhibitor of monoamine oxidase A [2] [3] that exhibits selective action on serotonin deamination.[4] Eprobemide differs from moclobemide only in the linker that connects the morpholine fragment with the chlorobenzamide — moclobemide has two carbon atoms while eprobemide has three. Its registration was cancelled on December 30, 2003.[5]
See also
[edit ]References
[edit ]- ^ Ganellin CR, Triggle DJ (1996). Dictionary of Pharmacological Agents. Vol. 3. p. 811. ISBN 978-0412466304.
- ^ Gol'dina OA, Moskvitina TA, Gankina EM, Kirkel' AZ, Kamyshanskaia NS, Lopatina KI, et al. (March 1991). "[The action of befol and its derivatives on monoamine oxidase of different origins]". Biulleten' Eksperimental'noi Biologii I Meditsiny. 111 (3): 279–80. PMID 2054504.
- ^ Donskaya NS, Antonkina OA, Glukhan EN, Smirnov SK (2004年07月01日). "Antidepressant Befol Synthesized Via Interaction of 4-Chloro-N-(3-chloropropyl)benzamide with Morpholine". Pharmaceutical Chemistry Journal. 0091-150X. 38 (7): 381–384. doi:10.1023/B:PHAC.0000048439.38383.5f. S2CID 29121452.
- ^ "Eprobemide". ChemIDplus.
- ^ "Befol". 4DOKTOR.RU Drug Information Handbook (in Russian). Retrieved 4 February 2014.
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