Integrin alpha 5

Protein

ITGA5

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3VI3, 3VI4, 4WJK, 4WK0, 4WK2, 4WK4

Identifiers

Aliases

ITGA5 , CD49e, FNRA, VLA5A, VLA-5, integrin subunit alpha 5

External IDs

OMIM: 135620; MGI: 96604; HomoloGene: 20508; GeneCards: ITGA5; OMA:ITGA5 - orthologs

Gene location (Human)
Chromosome 12 (human)
Chr.	Chromosome 12 (human) ^[1]
Chromosome 12 (human) Genomic location for ITGA5 Genomic location for ITGA5
Band	12q13.13	Start	54,395,261 bp ^[1]
Band	12q13.13	End	54,419,266 bp ^[1]

Gene location (Mouse)
Chromosome 15 (mouse)
Chr.	Chromosome 15 (mouse)^[2]
Chromosome 15 (mouse) Genomic location for ITGA5 Genomic location for ITGA5
Band	15 F3\|15 58.9 cM	Start	103,252,713 bp ^[2]
Band	15 F3\|15 58.9 cM	End	103,275,190 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in tibial arteries saphenous vein muscle layer of sigmoid colon Descending thoracic aorta stromal cell of endometrium ascending aorta smooth muscle tissue left uterine tube upper lobe of left lung right lung	Top expressed in tail of embryo decidua ascending aorta aortic valve gastrula stroma of bone marrow yolk sac genital tubercle atrium urinary bladder
More reference expression data

BioGPS

More reference expression data

Gene ontology
Molecular function	vascular endothelial growth factor receptor 2 binding virus receptor activity epidermal growth factor receptor binding metal ion binding platelet-derived growth factor receptor binding integrin binding protein binding cell adhesion molecule binding
Cellular component	cytoplasm integral component of membrane Golgi apparatus alphav-beta3 integrin-vitronectin complex membrane cell-cell junction ruffle plasma membrane synapse ruffle membrane cell surface integrin complex endoplasmic reticulum cytoplasmic vesicle external side of plasma membrane focal adhesion cell junction
Biological process	leukocyte cell-cell adhesion positive regulation of vascular endothelial growth factor receptor signaling pathway heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules endodermal cell differentiation positive regulation of cell migration heterotypic cell-cell adhesion wound healing, spreading of epidermal cells extracellular matrix organization memory cell-cell adhesion mediated by integrin positive regulation of sprouting angiogenesis cell-substrate adhesion cell adhesion angiogenesis positive regulation of peptidyl-tyrosine phosphorylation cell-substrate junction assembly integrin-mediated signaling pathway viral entry into host cell viral process negative regulation of anoikis leukocyte migration positive regulation of cell-substrate adhesion regulation of angiogenesis cell adhesion mediated by integrin female pregnancy
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3678


16402

Ensembl


ENSG00000161638


ENSMUSG00000000555

UniProt


P08648


P11688

RefSeq (mRNA)

NM_002205

NM_010577
NM_001314041

RefSeq (protein)

NP_002196

NP_001300970
NP_034707

Location (UCSC)

Chr 12: 54.4 – 54.42 Mb

Chr 15: 103.25 – 103.28 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.^[5]

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.^[6]

Interactions

[edit ]

ITGA5 has been shown to interact with GIPC1.^[7]

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161638 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000555 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (Aug 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest. 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653 . PMID 2454952.
^ "Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)".
^ Tani TT, Mercurio A M (Sep 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. 276 (39). United States: 36535–42. doi:10.1074/jbc.M105785200 . ISSN 0021-9258. PMID 11479315.

External links

[edit ]

CD49e+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
ITGA5 Info with links in the Cell Migration Gateway Archived 2014年12月11日 at the Wayback Machine
Overview of all the structural information available in the PDB for UniProt: P08648 (Human Integrin alpha-5) at the PDBe-KB.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350
351–371	CD351 CD352 CD353 CD354 CD355 CD357 CD358 CD360 CD361 CD362 CD363 CD364 CD365 CD366 CD367 CD368 CD369 CD370 CD371
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Integrin alpha 5

Interactions

See also

References

Further reading

External links