Integrin alpha 10
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Protein-coding gene in the species Homo sapiens
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| Aliases | ITGA10 , PRO827, integrin subunit alpha 10 | ||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 604042; MGI: 2153482; HomoloGene: 2697; GeneCards: ITGA10; OMA:ITGA10 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||
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Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene.[5] [6] [7]
Function
[edit ]Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue.[5]
Related gene problems
[edit ]References
[edit ]- ^ a b c GRCh38: Ensembl release 89: ENSG00000143127 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090210 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: ITGA10 integrin, alpha 10".
- ^ Camper L, Hellman U, Lundgren-Akerlund E (August 1998). "Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes". J. Biol. Chem. 273 (32): 20383–9. doi:10.1074/jbc.273.32.20383 . PMID 9685391.
- ^ Lehnert K, Ni J, Leung E, Gough S, Morris CM, Liu D, Wang SX, Langley R, Krissansen GW (1999). "The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization" . Cytogenet. Cell Genet. 87 (3–4): 238–44. doi:10.1159/000015434. PMID 10702680. S2CID 85257405.
- ^ Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342 . PMID 17236129.
Further reading
[edit ]- Camper L, Hellman U, Lundgren-Akerlund E (1998). "Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes". J. Biol. Chem. 273 (32): 20383–9. doi:10.1074/jbc.273.32.20383 . PMID 9685391.
- Bengtsson T, Camper L, Schneller M, Lundgren-Akerlund E (2001). "Characterization of the mouse integrin subunit alpha10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants". Matrix Biol. 20 (8): 565–76. doi:10.1016/S0945-053X(01)00164-0. PMID 11731273.
- Brakebusch C, Hirsch E, Potocnik A, Fässler R (1997). "Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules". J. Cell Sci. 110 (23): 2895–904. doi:10.1242/jcs.110.23.2895. PMID 9359872.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
- Lehnert K, Ni J, Leung E, et al. (1999). "The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization". Cytogenet. Cell Genet. 87 (3–4): 238–44. doi:10.1159/000015434. PMID 10702680. S2CID 85257405.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
- Svoboda KK (1998). "Chondrocyte-matrix attachment complexes mediate survival and differentiation". Microsc. Res. Tech. 43 (2): 111–22. doi:10.1002/(SICI)1097-0029(19981015)43:2<111::AID-JEMT4>3.0.CO;2-O . PMID 9822998. S2CID 15611353.
- Bengtsson T, Aszodi A, Nicolae C, et al. (2005). "Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes". J. Cell Sci. 118 (Pt 5): 929–36. doi:10.1242/jcs.01678 . PMID 15713743.
- Wenke AK, Rothhammer T, Moser M, Bosserhoff AK (2006). "Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1". Biochem. Biophys. Res. Commun. 345 (1): 495–501. doi:10.1016/j.bbrc.2006年04月12日3. PMID 16684505.
External links
[edit ]- ITGA10 Info with links in the Cell Migration Gateway Archived 2014年12月11日 at the Wayback Machine
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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