SLAMF8

Protein-coding gene in humans

SLAMF8

Identifiers

SLAMF8 , BLAME, CD353, SBBI42, SLAM family member 8

External IDs

OMIM: 606620; MGI: 1921998; HomoloGene: 10589; GeneCards: SLAMF8; OMA:SLAMF8 - orthologs

Gene location (Human)
Chromosome 1 (human)
Chr.	Chromosome 1 (human) ^[1]
Chromosome 1 (human) Genomic location for SLAMF8 Genomic location for SLAMF8
Band	1q23.2	Start	159,826,811 bp ^[1]
Band	1q23.2	End	159,837,492 bp ^[1]

Gene location (Mouse)
Chromosome 1 (mouse)
Chr.	Chromosome 1 (mouse)^[2]
Chromosome 1 (mouse) Genomic location for SLAMF8 Genomic location for SLAMF8
Band	1\|1 H3	Start	172,409,325 bp ^[2]
Band	1\|1 H3	End	172,418,135 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in appendix lymph node testicle lower lobe of lung decidua spleen superficial temporal artery amniotic fluid gallbladder rectum	Top expressed in mesenteric lymph nodes embryo spleen lumbar subsegment of spinal cord morula granulocyte right kidney blastocyst thymus subcutaneous adipose tissue
More reference expression data

BioGPS

More reference expression data

Gene ontology
Molecular function	signaling receptor activity identical protein binding
Cellular component	membrane integral component of membrane cell surface
Biological process	leukocyte chemotaxis involved in inflammatory response B-1 B cell lineage commitment negative regulation of macrophage chemotaxis regulation of NAD(P)H oxidase activity defense response to bacterium regulation of kinase activity regulation of B cell differentiation negative regulation of respiratory burst involved in inflammatory response negative regulation of monocyte chemotaxis phagosome acidification negative regulation of neutrophil migration negative regulation of dendritic cell chemotaxis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


56833


74748

Ensembl


ENSG00000158714


ENSMUSG00000053318

UniProt


Q9P0V8


Q9D3G2

RefSeq (mRNA)

NM_020125
NM_001330741

NM_029084

RefSeq (protein)

NP_001317670
NP_064510

NP_083360

Location (UCSC)

Chr 1: 159.83 – 159.84 Mb

Chr 1: 172.41 – 172.42 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

SLAM family member 8 is a protein that in humans is encoded by the SLAMF8 gene.^[5]^[6]

Function

[edit ]

This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes.^[6]

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158714 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053318 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kingsbury GA, Feeney LA, Nong Y, Calandra SA, Murphy CJ, Corcoran JM, Wang Y, Prabhu Das MR, Busfield SJ, Fraser CC, Villeval JL (May 2001). "Cloning, expression, and function of BLAME, a novel member of the CD2 family". Journal of Immunology. 166 (9): 5675–80. doi:10.4049/jimmunol.166.9.5675 . PMID 11313408.
^ ^a ^b "Entrez Gene: SLAMF8 SLAM family member 8".

Function

References

Further reading