One of the world’s least developed countries, Djibouti has seen a dramatic increase in poverty over the decades. Health system weaknesses, however, have not prevented improvements in reproductive health. Maternal mortality has declined and HIV prevalence has stabilized. Progress has been made by expanding quality reproductive health services, an initiative that UNFPA has backed since 1995. Current assistance focuses on generating high-quality data to inform public policies, expanding services to vulnerable populations, providing integrated support to survivors of gender-based violence, and engaging religious leaders in promoting reproductive health and rights.