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Schema
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Reaction
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Entries
MDH1 reduces OA
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authored
[InstanceEdit:9856870] Stephan, Ralf, 2023年12月26日
catalystActivity
[CatalystActivity:198512] L-malate dehydrogenase (NAD+) activity of MDH1 dimer [cytosol]
catalystActivityReference
[CatalystActivityReference:9815320] L-malate dehydrogenase activity of MDH1 dimer [cytosol] Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9856869] Stephan, Ralf, 2023年12月26日
crossReference
[DatabaseIdentifier:12610626] Rhea:21434
[DatabaseIdentifier:9856873] RHEA:21434
dbId
9856871
displayName
MDH1 reduces OA
edited
[InstanceEdit:9859599] Stephan, Ralf, 2024年01月22日
eventOf
[Pathway:R-HSA-9856872] Malate-aspartate shuttle - Homo sapiens
followingEvent
[Reaction:R-HSA-376851] SLC25A11 exchanges 2-OG and MAL - Homo sapiens
input
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-73473] NADH [cytosol]
[SimpleEntity:R-ALL-76213] OA [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:198443] Refined crystal structure of cytoplasmic malate dehydrogenase at 2.5-A resolution
[LiteratureReference:9815321] Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes
[LiteratureReference:198469] Developmental regulation and cellular distribution of human cytosolic malate dehydrogenase (MDH1)
[LiteratureReference:9854286] Cytosolic malate dehydrogenase regulates senescence in human fibroblasts
[LiteratureReference:9857025] MDH1 deficiency is a metabolic disorder of the malate-aspartate shuttle associated with early onset severe encephalopathy
[LiteratureReference:9857026] Structural Characterization of the Human Cytosolic Malate Dehydrogenase I
[LiteratureReference:9857057] The malate-aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway
maxDepth
1
modified
[InstanceEdit:10948619] Weiser, Joel, 2025年08月27日
name
MDH1 reduces OA
orthologousEvent
[Reaction:R-DRE-9856871] MDH1 reduces OA - Danio rerio
[Reaction:R-GGA-9856871] MDH1 reduces OA - Gallus gallus
[Reaction:R-SSC-9856871] MDH1 reduces OA - Sus scrofa
[Reaction:R-DDI-9856871] MDH1 reduces OA - Dictyostelium discoideum
[Reaction:R-XTR-9856871] MDH1 reduces OA - Xenopus tropicalis
[Reaction:R-DME-9856871] MDH1 reduces OA - Drosophila melanogaster
[Reaction:R-CEL-9856871] MDH1 reduces OA - Caenorhabditis elegans
[Reaction:R-BTA-9856871] MDH1 reduces OA - Bos taurus
[Reaction:R-CFA-9856871] MDH1 reduces OA - Canis familiaris
[Reaction:R-RNO-9856871] MDH1 reduces OA - Rattus norvegicus
[Reaction:R-MMU-9856871] MDH1 reduces OA - Mus musculus
output
[SimpleEntity:R-ALL-198498] MAL [cytosol]
[SimpleEntity:R-ALL-29360] NAD+ [cytosol]
precedingEvent
[Reaction:R-HSA-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Homo sapiens
[Reaction:R-HSA-70449] GADPH tetramer dehydrogenates GA3P - Homo sapiens
[Reaction:R-HSA-977348] PHGDH tetramer dehydrogenates 3PG - Homo sapiens
[Reaction:R-HSA-390251] HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA - Homo sapiens
[Reaction:R-HSA-6809264] EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA - Homo sapiens
previousReviewStatus
[ReviewStatus:9821383] three stars
releaseDate
2024年03月27日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9861220] Hill, David P, 2024年02月15日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9856871
summation
[Summation:198450] Cytosolic MDH1 (malate dehydrogenase 1) catalyzes the revers...
Referrals
(hasEvent)
[Pathway:R-HSA-9856872] Malate-aspartate shuttle
(precedingEvent)
[Reaction:R-HSA-376851] SLC25A11 exchanges 2-OG and MAL
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