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Schema
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Reaction
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Entries
PXLP-K259-GOT1 transaminates 2-OG and L-Asp
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catalystActivity
[CatalystActivity:70580] L-aspartate:2-oxoglutarate aminotransferase activity of PXLP-K259-GOT1 dimer [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
crossReference
[DatabaseIdentifier:9856908] RHEA:21825
[DatabaseIdentifier:12610593] Rhea:21825
dbId
70592
displayName
PXLP-K259-GOT1 transaminates 2-OG and L-Asp
eventOf
[Pathway:R-HSA-9856872] Malate-aspartate shuttle - Homo sapiens
followingEvent
[Reaction:R-HSA-8875623] SLC25A18,22 import L-Glu, H+ - Homo sapiens
[Reaction:R-HSA-70241] PCK1 phosphorylates OA to yield PEP - Homo sapiens
[Reaction:R-HSA-9856871] MDH1 reduces OA - Homo sapiens
[Reaction:R-HSA-9861660] ME1 tetramer decarboxylates OA to PYR - Homo sapiens
[Reaction:R-HSA-372448] SLC25A12,13 exchange L-Glu and L-Asp - Homo sapiens
input
[SimpleEntity:R-ALL-29406] 2OG [cytosol]
[SimpleEntity:R-ALL-29448] L-Asp [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:199740] The amino acid sequence of cytosolic aspartate aminotransferase from human liver
[LiteratureReference:9856996] Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors
maxDepth
1
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
PXLP-K259-GOT1 transaminates 2-OG and L-Asp
2-oxoglutarate + L-aspartate => L-glutamate + oxaloacetate
PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate
negativePrecedingEvent
[NegativePrecedingEvent:9930374] Futile Cycle: oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]
orthologousEvent
[Reaction:R-CEL-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Caenorhabditis elegans
[Reaction:R-DME-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Drosophila melanogaster
[Reaction:R-XTR-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Xenopus tropicalis
[Reaction:R-SSC-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Sus scrofa
[Reaction:R-BTA-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Bos taurus
[Reaction:R-SCE-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Saccharomyces cerevisiae
[Reaction:R-GGA-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Gallus gallus
[Reaction:R-CFA-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Canis familiaris
[Reaction:R-RNO-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Rattus norvegicus
[Reaction:R-SPO-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Schizosaccharomyces pombe
[Reaction:R-PFA-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Plasmodium falciparum
[Reaction:R-MMU-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Mus musculus
[Reaction:R-DRE-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Danio rerio
output
[SimpleEntity:R-ALL-29404] L-Glu [cytosol]
[SimpleEntity:R-ALL-76213] OA [cytosol]
precedingEvent
[Reaction:R-HSA-372480] 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] - Homo sapiens
[Reaction:R-HSA-372448] SLC25A12,13 exchange L-Glu and L-Asp - Homo sapiens
[Reaction:R-HSA-376851] SLC25A11 exchanges 2-OG and MAL - Homo sapiens
[Reaction:R-HSA-5691507] ASPA deacetylates NAASP to acetate and L-aspartate - Homo sapiens
[Reaction:R-HSA-6797627] ASPG hydrolyses L-Asn to L-Asp - Homo sapiens
releaseDate
2004年07月06日
reverseReaction
[Reaction:R-HSA-70581] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:376870] Harris, RA, 2008年09月10日 18:47:12
[InstanceEdit:9815859] Hill, David P, 2022年08月29日
revised
[InstanceEdit:9815860] D'Eustachio, Peter, 2022年08月29日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-70592
summation
[Summation:178477] Cytosolic GOT1 (glutamate oxaloacetate transaminase 1, also ...
updateTrackers
[UpdateTracker:9791761] Update Tracker - [Reaction:70592] PXLP-K259-GOT1 dimer deaminates L-Asp - v26:[modifyText]
[UpdateTracker:9790987] Update Tracker - [Reaction:70592] PXLP-K259-GOT1 dimer deaminates L-Asp - v32:[modifyText]
[UpdateTracker:9863990] Update Tracker - [Reaction:70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - v88:[addLiteratureReference, modifyText]
[UpdateTracker:9847075] Update Tracker - [Reaction:70592] PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate - v82:[modifyText]
[UpdateTracker:9846923] Update Tracker - [Reaction:70592] PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate - v83:[modifyText]
[UpdateTracker:9792268] Update Tracker - [Reaction:70592] PXLP-K259-GOT1 dimer deaminates L-Asp - v22:[addLiteratureReference]
Referrals
(precedingEvent)
[Reaction:R-HSA-8875623] SLC25A18,22 import L-Glu, H+
[Reaction:R-HSA-70241] PCK1 phosphorylates OA to yield PEP
[Reaction:R-HSA-372448] SLC25A12,13 exchange L-Glu and L-Asp
[Reaction:R-HSA-9856871] MDH1 reduces OA
[Reaction:R-HSA-9861660] ME1 tetramer decarboxylates OA to PYR
[NegativePrecedingEvent:9930390] Futile Cycle: PXLP-K259-GOT1 transaminates 2-OG and L-Asp
(hasEvent)
[Pathway:R-HSA-9856872] Malate-aspartate shuttle
[Pathway:R-HSA-8963693] Aspartate and asparagine metabolism
(updatedInstance)
[UpdateTracker:9791761] Update Tracker - [Reaction:70592] PXLP-K259-GOT1 dimer deaminates L-Asp - v26:[modifyText]
[UpdateTracker:9790987] Update Tracker - [Reaction:70592] PXLP-K259-GOT1 dimer deaminates L-Asp - v32:[modifyText]
[UpdateTracker:9863990] Update Tracker - [Reaction:70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - v88:[addLiteratureReference, modifyText]
[UpdateTracker:9847075] Update Tracker - [Reaction:70592] PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate - v82:[modifyText]
[UpdateTracker:9846923] Update Tracker - [Reaction:70592] PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate - v83:[modifyText]
[UpdateTracker:9792268] Update Tracker - [Reaction:70592] PXLP-K259-GOT1 dimer deaminates L-Asp - v22:[addLiteratureReference]
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