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Entries
STAT3 nuclear events downstream of ALK signaling
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authored
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9701899] Rothfels, Karen, 2020年09月28日
dbId
9701898
displayName
STAT3 nuclear events downstream of ALK signaling
edited
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
eventOf
[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-9701531] p-Y705,S727 STAT3 is acetylated - Homo sapiens
[Reaction:R-HSA-9701565] HDACs deacetylate p-STAT3 dimers - Homo sapiens
[Reaction:R-HSA-9701549] AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter - Homo sapiens
[BlackBoxEvent:R-HSA-9701548] PRDM1 gene expression downstream of ALK signaling - Homo sapiens
[Reaction:R-HSA-9701557] AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter - Homo sapiens
[Reaction:R-HSA-9851058] AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene - Homo sapiens
[BlackBoxEvent:R-HSA-9701556] IL2RG gene expression downstream of ALK signaling - Homo sapiens
[Reaction:R-HSA-9701534] p-Y705, S727 STAT3 dimer binds HIF1A gene - Homo sapiens
[BlackBoxEvent:R-HSA-9701569] ALK- and STAT3-dependent HIF1A gene expression - Homo sapiens
[Reaction:R-HSA-9701537] p-Y705, S727 STAT3 dimer binds CD274 gene - Homo sapiens
[BlackBoxEvent:R-HSA-9701562] CD274 gene expression downstream of ALK signaling - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9701290] Nucleophosmin-anaplastic lymphoma kinase: the ultimate oncogene and therapeutic target
[LiteratureReference:9701396] Revisiting STAT3 signalling in cancer: new and unexpected biological functions
[LiteratureReference:9701333] STAT3: a multifaceted oncoprotein
maxDepth
2
modified
[InstanceEdit:10948619] Weiser, Joel, 2025年08月27日
name
STAT3 nuclear events downstream of ALK signaling
orthologousEvent
[Pathway:R-DDI-9701898] STAT3 nuclear events downstream of ALK signaling - Dictyostelium discoideum
[Pathway:R-CEL-9701898] STAT3 nuclear events downstream of ALK signaling - Caenorhabditis elegans
[Pathway:R-DME-9701898] STAT3 nuclear events downstream of ALK signaling - Drosophila melanogaster
[Pathway:R-GGA-9701898] STAT3 nuclear events downstream of ALK signaling - Gallus gallus
[Pathway:R-XTR-9701898] STAT3 nuclear events downstream of ALK signaling - Xenopus tropicalis
[Pathway:R-SSC-9701898] STAT3 nuclear events downstream of ALK signaling - Sus scrofa
[Pathway:R-BTA-9701898] STAT3 nuclear events downstream of ALK signaling - Bos taurus
[Pathway:R-CFA-9701898] STAT3 nuclear events downstream of ALK signaling - Canis familiaris
[Pathway:R-RNO-9701898] STAT3 nuclear events downstream of ALK signaling - Rattus norvegicus
[Pathway:R-MMU-9701898] STAT3 nuclear events downstream of ALK signaling - Mus musculus
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2021年06月09日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9729891] Inghirami, Giorgio, 2021年05月04日
[InstanceEdit:9852935] Turner, Suzanne, 2023年11月08日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9701898
summation
[Summation:9701896] Activation of the STAT3 pathway downstream of ALK signaling ...
updateTrackers
[UpdateTracker:9853216] Update Tracker - [Pathway:9701898] STAT3 nuclear events downstream of ALK signaling - v87:[addHasEvent, updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9853216] Update Tracker - [Pathway:9701898] STAT3 nuclear events downstream of ALK signaling - v87:[addHasEvent, updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-201556] Signaling by ALK
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