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Schema
>
BlackBoxEvent
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Entries
IL2RG gene expression downstream of ALK signaling
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authored
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9701555] Rothfels, Karen, 2020年09月26日
dbId
9701556
displayName
IL2RG gene expression downstream of ALK signaling
edited
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
eventOf
[Pathway:R-HSA-9701898] STAT3 nuclear events downstream of ALK signaling - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-9701417] IL2RG gene [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9701314] The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3
maxDepth
1
modified
[InstanceEdit:9853043] Rothfels, Karen, 2023年11月09日
name
IL2RG gene expression downstream of ALK signaling
output
[EntityWithAccessionedSequence:R-HSA-449139] IL2RG [plasma membrane]
precedingEvent
[Reaction:R-HSA-9701557] AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
regulatedBy
[NegativeGeneExpressionRegulation:9701545] Negative gene expression regulation by 'SIN3A:ACK685-p-Y705,S727 STAT3 dimer:IL2RG gene [nucleoplasm]'
[NegativeGeneExpressionRegulation:9850955] Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]'
regulationReference
[RegulationReference:9850959] Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]' IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
[RegulationReference:9850957] Negative gene expression regulation by 'SIN3A:ACK685-p-Y705,S727 STAT3 dimer:IL2RG gene [nucleoplasm]' The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3
releaseDate
2021年06月09日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9729891] Inghirami, Giorgio, 2021年05月04日
[InstanceEdit:9852935] Turner, Suzanne, 2023年11月08日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9701556
summation
[Summation:9701554] IL2RG gene expression is repressed by a complex of SIN3A and...
updateTrackers
[UpdateTracker:9853282] Update Tracker - [BlackBoxEvent:9701556] IL2RG gene expression downstream of ALK signaling - v87:[addRegulator]
Referrals
(updatedInstance)
[UpdateTracker:9853282] Update Tracker - [BlackBoxEvent:9701556] IL2RG gene expression downstream of ALK signaling - v87:[addRegulator]
(hasEvent)
[Pathway:R-HSA-9701898] STAT3 nuclear events downstream of ALK signaling
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