Reactome Pathway Database

Schema > NegativeGeneExpressionRegulation > Entries

Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]' Show undefined attributes

activeUnit

created [InstanceEdit:9850956] Rothfels, Karen, 2023年10月12日

dbId 9850955

displayName Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]'

regulatedEntity

[BlackBoxEvent:R-HSA-9701556] IL2RG gene expression downstream of ALK signaling - Homo sapiens

regulator [Complex:R-HSA-9850883] DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]

schemaClass NegativeGeneExpressionRegulation

Referrals

(regulation)

[RegulationReference:9850959] Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]' IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK

(regulatedBy)

[BlackBoxEvent:R-HSA-9701556] IL2RG gene expression downstream of ALK signaling

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