Reactome Pathway Database

Schema > Reaction > Entries

AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene Show undefined attributes

authored

[InstanceEdit:9851210] Rothfels, Karen, 2023年10月14日

category binding

compartment

[Compartment:7660] nucleoplasm

created [InstanceEdit:9851059] Rothfels, Karen, 2023年10月12日

dbId 9851058

displayName AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene

edited

[InstanceEdit:9851215] Rothfels, Karen, 2023年10月14日

eventOf

[Pathway:R-HSA-9701898] STAT3 nuclear events downstream of ALK signaling - Homo sapiens

input

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:9701299] IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK

maxDepth 1

modified [InstanceEdit:9852942] Rothfels, Karen, 2023年11月08日

name

AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene

output

[Complex:R-HSA-9850883] DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]

precedingEvent

[Reaction:R-HSA-9701531] p-Y705,S727 STAT3 is acetylated - Homo sapiens

releaseDate 2023年12月06日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9852935] Turner, Suzanne, 2023年11月08日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9851058

summation

[Summation:9850805] STAT3 recruits DNMT1 to the IL2RG promoter in NPM1-ALK cells...

Referrals

(hasEvent)

[Pathway:R-HSA-9701898] STAT3 nuclear events downstream of ALK signaling

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