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Schema
>
Reaction
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Entries
Activated FGFR4:p-FRS bind to PPTN11
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authored
[InstanceEdit:190908] de Bono, B, 2007年01月10日 10:27:18
category
binding
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:5654656] Rothfels, Karen, 2014年12月03日
dbId
5654658
deleted
[Deleted:5655565] Deletion of instance: 190358
displayName
Activated FGFR4:p-FRS bind to PPTN11
edited
[InstanceEdit:500337] Jupe, S, 2010年02月03日
eventOf
[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling - Homo sapiens
followingEvent
[Reaction:R-HSA-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Homo sapiens
[Reaction:R-HSA-5654655] Activated FGFR4 phosphorylates PPTN11 - Homo sapiens
input
[DefinedSet:R-HSA-5654324] Activated FGFR4:p-FRS [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-162563] PTPN11 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3
[LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
Activated FGFR4:p-FRS bind to PPTN11
orthologousEvent
[Reaction:R-RNO-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Rattus norvegicus
[Reaction:R-GGA-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Gallus gallus
[Reaction:R-XTR-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Xenopus tropicalis
[Reaction:R-SSC-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Sus scrofa
[Reaction:R-BTA-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Bos taurus
[Reaction:R-CFA-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Canis familiaris
[Reaction:R-MMU-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Mus musculus
output
[Complex:R-HSA-5654337] Activated FGFR4:p-FRS:PTPN11 [plasma membrane]
precedingEvent
[Reaction:R-HSA-5654418] Activated FGFR4 phosphorylates FRS2 - Homo sapiens
[Reaction:R-HSA-5654653] Activated FGFR4 phosphorylates FRS3 - Homo sapiens
releaseDate
2010年03月16日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:192607] Mohammadi, M, 2007年02月06日 21:44:35
[InstanceEdit:1549563] Gotoh, N, 2011年08月26日
revised
[InstanceEdit:1493881] Rothfels, K, 2011年08月16日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5654658
summation
[Summation:1268151] p-FRS2 has two PPTN11/SHP2-binding sites at pY436 and pY471.
Referrals
(replacementInstances)
[Deleted:5655565] Deletion of instance: 190358
(hasEvent)
[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling
(precedingEvent)
[Reaction:R-HSA-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
[Reaction:R-HSA-5654655] Activated FGFR4 phosphorylates PPTN11
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