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Schema
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Reaction
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Entries
Activated FGFR4 phosphorylates FRS3
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authored
[InstanceEdit:190908] de Bono, B, 2007年01月10日 10:27:18
catalystActivity
[CatalystActivity:5654654] protein tyrosine kinase activity of Activated FGFR4:FRS3 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created
[InstanceEdit:5654652] Rothfels, Karen, 2014年12月03日
dbId
5654653
deleted
[Deleted:5655566] Deletion of instance: 191471
displayName
Activated FGFR4 phosphorylates FRS3
edited
[InstanceEdit:500337] Jupe, S, 2010年02月03日
eventOf
[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling - Homo sapiens
followingEvent
[Reaction:R-HSA-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Homo sapiens
[Reaction:R-HSA-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Homo sapiens
input
[Complex:R-HSA-5654319] Activated FGFR4:FRS3 [plasma membrane]
5 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:189823] A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
[LiteratureReference:1268094] The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Activated FGFR4 phosphorylates FRS3
orthologousEvent
[Reaction:R-RNO-5654653] Activated FGFR4 phosphorylates FRS3 - Rattus norvegicus
[Reaction:R-CEL-5654653] Activated FGFR4 phosphorylates FRS3 - Caenorhabditis elegans
[Reaction:R-DME-5654653] Activated FGFR4 phosphorylates FRS3 - Drosophila melanogaster
[Reaction:R-GGA-5654653] Activated FGFR4 phosphorylates FRS3 - Gallus gallus
[Reaction:R-XTR-5654653] Activated FGFR4 phosphorylates FRS3 - Xenopus tropicalis
[Reaction:R-DRE-5654653] Activated FGFR4 phosphorylates FRS3 - Danio rerio
[Reaction:R-SSC-5654653] Activated FGFR4 phosphorylates FRS3 - Sus scrofa
[Reaction:R-BTA-5654653] Activated FGFR4 phosphorylates FRS3 - Bos taurus
[Reaction:R-CFA-5654653] Activated FGFR4 phosphorylates FRS3 - Canis familiaris
[Reaction:R-MMU-5654653] Activated FGFR4 phosphorylates FRS3 - Mus musculus
output
[Complex:R-HSA-5654326] Activated FGFR4:p-FRS3 [plasma membrane]
5 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent
[Reaction:R-HSA-5654651] Activated FGFR4 binds FRS3 - Homo sapiens
releaseDate
2010年03月16日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:192607] Mohammadi, M, 2007年02月06日 21:44:35
[InstanceEdit:1549563] Gotoh, N, 2011年08月26日
revised
[InstanceEdit:1493881] Rothfels, K, 2011年08月16日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5654653
summation
[Summation:191523] FRS3 (also known as FRS2 beta) is activated through tyrosine...
Referrals
(replacementInstances)
[Deleted:5655566] Deletion of instance: 191471
(hasEvent)
[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling
(precedingEvent)
[Reaction:R-HSA-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1
[Reaction:R-HSA-5654658] Activated FGFR4:p-FRS bind to PPTN11
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