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Schema
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Reaction
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Entries
Activated FGFR3 phosphorylates FRS2
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authored
[InstanceEdit:190908] de Bono, B, 2007年01月10日 10:27:18
catalystActivity
[CatalystActivity:5654411] protein tyrosine kinase activity of Activated FGFR3:FRS2 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created
[InstanceEdit:5654410] Rothfels, Karen, 2014年12月03日
dbId
5654408
deleted
[Deleted:5655568] Deletion of instance: 190353
displayName
Activated FGFR3 phosphorylates FRS2
edited
[InstanceEdit:500337] Jupe, S, 2010年02月03日
eventOf
[Pathway:R-HSA-5654706] FRS-mediated FGFR3 signaling - Homo sapiens
followingEvent
[Reaction:R-HSA-5654416] Activated FGFR3:pFRS binds GRB2:SOS1 - Homo sapiens
[Reaction:R-HSA-5654637] Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens
[Reaction:R-HSA-5654633] Activated FGFR3:p-FRS bind to PPTN11 - Homo sapiens
input
[Complex:R-HSA-5654180] Activated FGFR3:FRS2 [plasma membrane]
6 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:532232] Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2
[LiteratureReference:189823] A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
[LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
Activated FGFR3 phosphorylates FRS2
orthologousEvent
[Reaction:R-DME-5654408] Activated FGFR3 phosphorylates FRS2 - Drosophila melanogaster
[Reaction:R-GGA-5654408] Activated FGFR3 phosphorylates FRS2 - Gallus gallus
[Reaction:R-BTA-5654408] Activated FGFR3 phosphorylates FRS2 - Bos taurus
[Reaction:R-CFA-5654408] Activated FGFR3 phosphorylates FRS2 - Canis familiaris
[Reaction:R-RNO-5654408] Activated FGFR3 phosphorylates FRS2 - Rattus norvegicus
[Reaction:R-MMU-5654408] Activated FGFR3 phosphorylates FRS2 - Mus musculus
output
[Complex:R-HSA-5654196] Activated FGFR3:p-FRS2 [plasma membrane]
6 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent
[Reaction:R-HSA-5654409] Activated FGFR3 binds FRS2 - Homo sapiens
regulatedBy
[NegativeRegulation:R-HSA-5654412] Negative regulation by 'Activated FGFR3:p-8T-FRS2 [plasma membrane]'
releaseDate
2010年03月16日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:192607] Mohammadi, M, 2007年02月06日 21:44:35
[InstanceEdit:1549563] Gotoh, N, 2011年08月26日
revised
[InstanceEdit:1493881] Rothfels, K, 2011年08月16日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5654408
summation
[Summation:191507] FRS2 (also known as FRS alpha is activated through tyrosine...
Referrals
(replacementInstances)
[Deleted:5655568] Deletion of instance: 190353
(normalReaction)
[Reaction:R-HSA-5655270] Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2
(hasEvent)
[Pathway:R-HSA-5654706] FRS-mediated FGFR3 signaling
(precedingEvent)
[Reaction:R-HSA-5654416] Activated FGFR3:pFRS binds GRB2:SOS1
[Reaction:R-HSA-5654637] Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
[Reaction:R-HSA-5654633] Activated FGFR3:p-FRS bind to PPTN11
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