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Schema
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Reaction
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Entries
Activated FGFR3:pFRS binds GRB2:SOS1
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authored
[InstanceEdit:1489508] Rothfels, K, 2011年08月15日
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:5654414] Rothfels, Karen, 2014年12月03日
dbId
5654416
deleted
[Deleted:5655561] Deletion of instance: 1268255
displayName
Activated FGFR3:pFRS binds GRB2:SOS1
eventOf
[Pathway:R-HSA-5654706] FRS-mediated FGFR3 signaling - Homo sapiens
followingEvent
[Reaction:R-HSA-5654413] Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens
[Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange - Homo sapiens
input
[DefinedSet:R-HSA-5654305] Activated FGFR3:p-FRS [plasma membrane]
[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:189823] A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
[LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
[LiteratureReference:532232] Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2
[LiteratureReference:532244] Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells
[LiteratureReference:191015] Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
Activated FGFR3:pFRS binds GRB2:SOS1
orthologousEvent
[Reaction:R-DME-5654416] Activated FGFR3:pFRS binds GRB2:SOS1 - Drosophila melanogaster
[Reaction:R-GGA-5654416] Activated FGFR3:pFRS binds GRB2:SOS1 - Gallus gallus
[Reaction:R-DRE-5654416] Activated FGFR3:pFRS binds GRB2:SOS1 - Danio rerio
[Reaction:R-BTA-5654416] Activated FGFR3:pFRS binds GRB2:SOS1 - Bos taurus
[Reaction:R-CFA-5654416] Activated FGFR3:pFRS binds GRB2:SOS1 - Canis familiaris
[Reaction:R-RNO-5654416] Activated FGFR3:pFRS binds GRB2:SOS1 - Rattus norvegicus
[Reaction:R-MMU-5654416] Activated FGFR3:pFRS binds GRB2:SOS1 - Mus musculus
output
[Complex:R-HSA-5654308] Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-5654408] Activated FGFR3 phosphorylates FRS2 - Homo sapiens
[Reaction:R-HSA-5654628] Activated FGFR3 phosphorylates FRS3 - Homo sapiens
releaseDate
2011年09月20日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1549563] Gotoh, N, 2011年08月26日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5654416
summation
[Summation:1268254] Tyrosine phosphorylated FRS2 recruits GRB2:SOS1 complex by m...
Referrals
(replacementInstances)
[Deleted:5655561] Deletion of instance: 1268255
(normalReaction)
[Reaction:R-HSA-5655295] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1
(hasEvent)
[Pathway:R-HSA-5654706] FRS-mediated FGFR3 signaling
(precedingEvent)
[Reaction:R-HSA-5654413] Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
[Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange
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