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Entries
Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1
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authored
[InstanceEdit:2105031] Rothfels, K, 2012年02月09日
category
binding
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:5655319] Rothfels, Karen, 2014年12月05日
crossReference
[DatabaseIdentifier:11944971] Mondo:0005497
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
5655295
deleted
[Deleted:9768280] Deletion of instance: 8853314
[Deleted:5655668] Deletion of instance: 1982082
disease
[Disease:1500689] cancer
[Disease:2032940] bone development disease
displayName
Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1
edited
[InstanceEdit:2252592] Rothfels, K, 2012年05月16日
entityFunctionalStatus
[EntityFunctionalStatus:5655314] gain_of_function of Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane]
eventOf
[Pathway:R-HSA-5655332] Signaling by FGFR3 in disease - Homo sapiens
input
[Complex:R-HSA-5655238] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane]
[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
[LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer
[LiteratureReference:1295608] Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4
[LiteratureReference:2054036] Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation
[LiteratureReference:8852916] Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours
[LiteratureReference:8852907] Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1
normalReaction
[Reaction:R-HSA-5654416] Activated FGFR3:pFRS binds GRB2:SOS1
output
[Complex:R-HSA-5655307] FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012年05月15日
[InstanceEdit:8853855] Grose, Richard P, 2016年01月25日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5655295
summation
[Summation:9753854] Activation of FGFR mutants has in some cases been shown to r...
updateTrackers
[UpdateTracker:9775338] Update Tracker - [Reaction:5655295] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1 - v79:[addLiteratureReference, add_removeSummation]
Referrals
(updatedInstance)
[UpdateTracker:9775338] Update Tracker - [Reaction:5655295] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1 - v79:[addLiteratureReference, add_removeSummation]
(replacementInstances)
[Deleted:5655668] Deletion of instance: 1982082
[Deleted:9768280] Deletion of instance: 8853314
(hasEvent)
[Pathway:R-HSA-5655332] Signaling by FGFR3 in disease
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