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Entries
Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2
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authored
[InstanceEdit:2105031] Rothfels, K, 2012年02月09日
catalystActivity
[CatalystActivity:5655298] protein tyrosine kinase activity of Activated FGFR3 point, translocation and fusion mutants:FRS2 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:5655319] Rothfels, Karen, 2014年12月05日
crossReference
[DatabaseIdentifier:11944971] Mondo:0005497
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
5655270
deleted
[Deleted:9768275] Deletion of instance: 8853315
[Deleted:5655667] Deletion of instance: 1982077
disease
[Disease:1500689] cancer
[Disease:2032940] bone development disease
displayName
Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2
edited
[InstanceEdit:2252592] Rothfels, K, 2012年05月16日
entityFunctionalStatus
[EntityFunctionalStatus:5655239] gain_of_function of Activated FGFR3 point, translocation and fusion mutants:FRS2 [plasma membrane]
eventOf
[Pathway:R-HSA-5655332] Signaling by FGFR3 in disease - Homo sapiens
input
[Complex:R-HSA-5655312] Activated FGFR3 point, translocation and fusion mutants:FRS2 [plasma membrane]
6 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer
[LiteratureReference:1307938] Fibroblast growth factor signalling: from development to cancer
[LiteratureReference:2033241] Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice
[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
[LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor
[LiteratureReference:2067711] GP369, an FGFR2-IIIb-specific antibody, exhibits potent antitumor activity against human cancers driven by activated FGFR2 signaling
[LiteratureReference:1268074] Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling
[LiteratureReference:2054036] Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation
[LiteratureReference:8852916] Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours
[LiteratureReference:8852907] Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2
normalReaction
[Reaction:R-HSA-5654408] Activated FGFR3 phosphorylates FRS2
output
[Complex:R-HSA-5655238] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane]
6 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012年05月15日
[InstanceEdit:8853855] Grose, Richard P, 2016年01月25日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5655270
summation
[Summation:9753850] After recruitment to activated FGFR mutants, FRS2 is believe...
updateTrackers
[UpdateTracker:9775375] Update Tracker - [Reaction:5655270] Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2 - v79:[addLiteratureReference, add_removeSummation]
Referrals
(updatedInstance)
[UpdateTracker:9775375] Update Tracker - [Reaction:5655270] Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2 - v79:[addLiteratureReference, add_removeSummation]
(replacementInstances)
[Deleted:5655667] Deletion of instance: 1982077
[Deleted:9768275] Deletion of instance: 8853315
(hasEvent)
[Pathway:R-HSA-5655332] Signaling by FGFR3 in disease
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