Reactome Pathway Database

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Activated FGFR3:p-FRS bind to PPTN11 Show undefined attributes

authored

[InstanceEdit:190908] de Bono, B, 2007年01月10日 10:27:18

category binding

compartment

created [InstanceEdit:5654632] Rothfels, Karen, 2014年12月03日

dbId 5654633

deleted

[Deleted:5655565] Deletion of instance: 190358

displayName Activated FGFR3:p-FRS bind to PPTN11

edited

[InstanceEdit:500337] Jupe, S, 2010年02月03日

eventOf

[Pathway:R-HSA-5654706] FRS-mediated FGFR3 signaling - Homo sapiens

followingEvent

[Reaction:R-HSA-5654631] Activated FGFR3 phosphorylates PPTN11 - Homo sapiens

input

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

name

Activated FGFR3:p-FRS bind to PPTN11

orthologousEvent

output

[Complex:R-HSA-5654310] Activated FGFR3:p-FRS:PTPN11 [plasma membrane]

precedingEvent

releaseDate 2010年03月16日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

revised

[InstanceEdit:1493881] Rothfels, K, 2011年08月16日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-5654633

summation

[Summation:1268151] p-FRS2 has two PPTN11/SHP2-binding sites at pY436 and pY471.

Referrals

(replacementInstances)

[Deleted:5655565] Deletion of instance: 190358

(hasEvent)

[Pathway:R-HSA-5654706] FRS-mediated FGFR3 signaling

(precedingEvent)

[Reaction:R-HSA-5654631] Activated FGFR3 phosphorylates PPTN11

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