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Schema
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Reaction
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Entries
NR1H4 binds DCA, CDCA, LCHA
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authored
[InstanceEdit:5340205] Jassal, Bijay, 2014年03月12日
catalystActivity
[CatalystActivity:9917215] bile acid nuclear receptor activity of NR1H4 [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5340205] Jassal, Bijay, 2014年03月12日
dbId
5340195
displayName
NR1H4 binds DCA, CDCA, LCHA
edited
[InstanceEdit:5340205] Jassal, Bijay, 2014年03月12日
eventOf
[Pathway:R-HSA-159418] Recycling of bile acids and salts - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-1989746] Expression of CYP7A1 - Homo sapiens
[Reaction:R-HSA-5340251] NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 - Homo sapiens
[Reaction:R-HSA-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Homo sapiens
[Reaction:R-HSA-192051] CYP7A1 7-hydroxylates CHOL - Homo sapiens
[Reaction:R-HSA-192065] CYP7B1 7-hydroxylates 25OH-CHOL - Homo sapiens
[Reaction:R-HSA-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - Homo sapiens
input
[DefinedSet:R-ALL-5340249] DCA,CDCA,LCHA [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-5340228] NR1H4 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5340187] Bile acids: natural ligands for an orphan nuclear receptor
[LiteratureReference:444825] Identification of a nuclear receptor for bile acids
[LiteratureReference:5340192] Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation
[LiteratureReference:5340252] Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis
[LiteratureReference:5340220] Endocrine functions of bile acids
[LiteratureReference:5340210] FXR, a multipurpose nuclear receptor
[LiteratureReference:5340256] Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump
[LiteratureReference:5340271] Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
NR1H4 binds DCA, CDCA, LCHA
FXR binds bile acids
orthologousEvent
[Reaction:R-DME-5340195] NR1H4 binds DCA, CDCA, LCHA - Drosophila melanogaster
[Reaction:R-GGA-5340195] NR1H4 binds DCA, CDCA, LCHA - Gallus gallus
[Reaction:R-XTR-5340195] NR1H4 binds DCA, CDCA, LCHA - Xenopus tropicalis
[Reaction:R-DRE-5340195] NR1H4 binds DCA, CDCA, LCHA - Danio rerio
[Reaction:R-SSC-5340195] NR1H4 binds DCA, CDCA, LCHA - Sus scrofa
[Reaction:R-BTA-5340195] NR1H4 binds DCA, CDCA, LCHA - Bos taurus
[Reaction:R-CFA-5340195] NR1H4 binds DCA, CDCA, LCHA - Canis familiaris
[Reaction:R-RNO-5340195] NR1H4 binds DCA, CDCA, LCHA - Rattus norvegicus
[Reaction:R-MMU-5340195] NR1H4 binds DCA, CDCA, LCHA - Mus musculus
output
[Complex:R-HSA-5340186] NR1H4:DCA,CDCA,LCHA [nucleoplasm]
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2015年03月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5674208] D'Eustachio, Peter, 2015年02月11日
[InstanceEdit:9917333] Hill, David P, 2024年08月02日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5340195
summation
[Summation:5340176] The nuclear orphan protein bile acid receptor aka farnesoid ...
updateTrackers
[UpdateTracker:9919429] Update Tracker - [Reaction:5340195] NR1H4 binds DCA, CDCA, LCHA - v90:[removeCatalystActivity]
Referrals
(updatedInstance)
[UpdateTracker:9919429] Update Tracker - [Reaction:5340195] NR1H4 binds DCA, CDCA, LCHA - v90:[removeCatalystActivity]
(precedingEvent)
[BlackBoxEvent:R-HSA-1989746] Expression of CYP7A1
[Reaction:R-HSA-5340251] NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2
[Reaction:R-HSA-191972] 27-hydroxycholesterol is 7alpha-hydroxylated
[Reaction:R-HSA-192051] CYP7A1 7-hydroxylates CHOL
[Reaction:R-HSA-192065] CYP7B1 7-hydroxylates 25OH-CHOL
[Reaction:R-HSA-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol
(hasEvent)
[Pathway:R-HSA-159418] Recycling of bile acids and salts
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