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Schema
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Reaction
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Entries
27-hydroxycholesterol is 7alpha-hydroxylated
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authored
[InstanceEdit:191331] Jassal, Bijay, 2007年01月19日
catalystActivity
[CatalystActivity:192095] oxysterol 7-alpha-hydroxylase activity of Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created
[InstanceEdit:191989] Jassal, Bijay, 2007年01月26日
dbId
191972
displayName
27-hydroxycholesterol is 7alpha-hydroxylated
edited
[InstanceEdit:197117] D'Eustachio, P, 2007年04月30日 14:43:26
eventOf
[Pathway:R-HSA-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Homo sapiens
followingEvent
[Reaction:R-HSA-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Homo sapiens
input
[SimpleEntity:R-ALL-176617] 27HCHOL [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-29364] NADPH [cytosol]
[SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:191992] Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
27-hydroxycholesterol is 7alpha-hydroxylated
27-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,27-triol + H2O + NADP+
orthologousEvent
[Reaction:R-GGA-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Gallus gallus
[Reaction:R-XTR-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Xenopus tropicalis
[Reaction:R-SSC-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Sus scrofa
[Reaction:R-BTA-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Bos taurus
[Reaction:R-CFA-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Canis familiaris
[Reaction:R-RNO-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Rattus norvegicus
[Reaction:R-MMU-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Mus musculus
output
[SimpleEntity:R-ALL-192194] Cholest-5-ene-3beta,7alpha,27-triol [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent
[Reaction:R-HSA-5340195] NR1H4 binds DCA, CDCA, LCHA - Homo sapiens
regulatedBy
[NegativeRegulation:R-HSA-5340418] Negative regulation by 'NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm]'
releaseDate
2007年05月15日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:197117] D'Eustachio, P, 2007年04月30日 14:43:26
revised
[InstanceEdit:5674206] Jassal, Bijay, 2015年02月11日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-191972
summation
[Summation:193810] 27-hydroxycholesterol, NADPH + H+, and O2 react to form chol...
updateTrackers
[UpdateTracker:9786376] Update Tracker - [Reaction:191972] 27-hydroxycholesterol is 7alpha-hydroxylated - v49:[addRegulator]
Referrals
(updatedInstance)
[UpdateTracker:9786376] Update Tracker - [Reaction:191972] 27-hydroxycholesterol is 7alpha-hydroxylated - v49:[addRegulator]
(hasEvent)
[Pathway:R-HSA-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol
(precedingEvent)
[Reaction:R-HSA-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one
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