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Schema
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Reaction
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Entries
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one
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authored
[InstanceEdit:193805] D'Eustachio, P, 2007年02月27日 21:49:11
catalystActivity
[CatalystActivity:192106] 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity of HSD3B7 [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created
[InstanceEdit:193803] D'Eustachio, P, 2007年02月27日 22:01:10
dbId
193816
displayName
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one
edited
[InstanceEdit:193805] D'Eustachio, P, 2007年02月27日 21:49:11
eventOf
[Pathway:R-HSA-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Homo sapiens
followingEvent
[Reaction:R-HSA-193824] 4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one - Homo sapiens
[Reaction:R-HSA-193845] CYP8B1 12-hydroxylates 4CHOL7a,27DONE - Homo sapiens
input
[SimpleEntity:R-ALL-192194] Cholest-5-ene-3beta,7alpha,27-triol [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:193374] Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease
[LiteratureReference:193532] The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis
maxDepth
1
modified
[InstanceEdit:10603480] Weiser, Joel, 2025年08月27日
name
Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one
Cholest-5-ene-3beta,7alpha,27-triol + NAD+ => 4-cholesten-7alpha,27-diol-3-one +NADH + H+
orthologousEvent
[Reaction:R-XTR-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Xenopus tropicalis
[Reaction:R-DRE-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Danio rerio
[Reaction:R-SSC-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Sus scrofa
[Reaction:R-BTA-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Bos taurus
[Reaction:R-CFA-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Canis familiaris
[Reaction:R-RNO-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Rattus norvegicus
[Reaction:R-MMU-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Mus musculus
output
[SimpleEntity:R-ALL-193835] 4CHOL7a,27DONE [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent
[Reaction:R-HSA-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Homo sapiens
releaseDate
2007年05月15日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:197117] D'Eustachio, P, 2007年04月30日 14:43:26
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-193816
summation
[Summation:193797] Cholest-5-ene-3beta,7alpha,27-triol and NAD+ react to form 4...
Referrals
(hasEvent)
[Pathway:R-HSA-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol
(precedingEvent)
[Reaction:R-HSA-193824] 4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one
[Reaction:R-HSA-193845] CYP8B1 12-hydroxylates 4CHOL7a,27DONE
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