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Synthesis of bile acids and bile salts via 27-hydroxycholesterol
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authored
[InstanceEdit:193805] D'Eustachio, P, 2007年02月27日 21:49:11
created
[InstanceEdit:193803] D'Eustachio, P, 2007年02月27日 22:01:10
dbId
193807
displayName
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
edited
[InstanceEdit:193805] D'Eustachio, P, 2007年02月27日 21:49:11
eventOf
[Pathway:R-HSA-192105] Synthesis of bile acids and bile salts - Homo sapiens
figure
[Figure:193796] /figures/27oxy_pathway.jpg
goBiologicalProcess
[GO_BiologicalProcess:20533] bile acid biosynthetic process
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-192123] CYP27A1 27-hydroxylates CHOL - Homo sapiens
[BlackBoxEvent:R-HSA-193812] Efflux of 27-hydroxycholesterol - Homo sapiens
[BlackBoxEvent:R-HSA-193801] Influx of 27-hydroxycholesterol - Homo sapiens
[Reaction:R-HSA-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Homo sapiens
[Reaction:R-HSA-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Homo sapiens
[Reaction:R-HSA-193845] CYP8B1 12-hydroxylates 4CHOL7a,27DONE - Homo sapiens
[Reaction:R-HSA-193821] 4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one - Homo sapiens
[Reaction:R-HSA-193824] 4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one - Homo sapiens
[Reaction:R-HSA-193800] 5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol - Homo sapiens
[Reaction:R-HSA-193841] 5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol - Homo sapiens
[Reaction:R-HSA-193832] 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is translocated from the cytosol to the mitochondrial matrix - Homo sapiens
[Reaction:R-HSA-193808] 5beta-cholestan-3alpha,7alpha,27-triol is translocated from the cytosol to the mitochondrial matrix - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2018年09月30日
literatureReference
[LiteratureReference:193802] Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin
[LiteratureReference:193818] Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages
[LiteratureReference:193584] Cholesterol, hydroxycholesterols, and bile acids
[LiteratureReference:192080] The enzymes, regulation, and genetics of bile acid synthesis
maxDepth
2
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
orthologousEvent
[Pathway:R-SCE-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Saccharomyces cerevisiae
[Pathway:R-SPO-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Schizosaccharomyces pombe
[Pathway:R-DDI-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Dictyostelium discoideum
[Pathway:R-CEL-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Caenorhabditis elegans
[Pathway:R-DME-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Drosophila melanogaster
[Pathway:R-GGA-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Gallus gallus
[Pathway:R-XTR-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Xenopus tropicalis
[Pathway:R-DRE-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Danio rerio
[Pathway:R-SSC-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Sus scrofa
[Pathway:R-BTA-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Bos taurus
[Pathway:R-CFA-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Canis familiaris
[Pathway:R-RNO-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Rattus norvegicus
[Pathway:R-MMU-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Mus musculus
releaseDate
2007年05月15日
releaseStatus
UPDATED
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:197117] D'Eustachio, P, 2007年04月30日 14:43:26
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-193807
summation
[Summation:193827] In the body, 27-hydroxycholesterol is synthesized in multipl...
updateTrackers
[UpdateTracker:9786395] Update Tracker - [Pathway:193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - v49:[updateContainedRLE]
[UpdateTracker:9779170] Update Tracker - [Pathway:193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - v66:[updateContainedRLE]
[UpdateTracker:9792231] Update Tracker - [Pathway:193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - v22:[updateContainedRLE]
[UpdateTracker:9786350] Update Tracker - [Pathway:193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - v50:[updateContainedRLE]
[UpdateTracker:9911018] Update Tracker - [Pathway:193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - v89:[updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9786395] Update Tracker - [Pathway:193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - v49:[updateContainedRLE]
[UpdateTracker:9779170] Update Tracker - [Pathway:193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - v66:[updateContainedRLE]
[UpdateTracker:9792231] Update Tracker - [Pathway:193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - v22:[updateContainedRLE]
[UpdateTracker:9786350] Update Tracker - [Pathway:193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - v50:[updateContainedRLE]
[UpdateTracker:9911018] Update Tracker - [Pathway:193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - v89:[updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-192105] Synthesis of bile acids and bile salts
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