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Entries
CYP7A1 7-hydroxylates CHOL
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authored
[InstanceEdit:350358] Jassal, Bijay, 2008年05月19日
catalystActivity
[CatalystActivity:192120] cholesterol 7-alpha-monooxygenase activity of Cytochrome P450 (CYP7A1 based) [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created
[InstanceEdit:191989] Jassal, Bijay, 2007年01月26日
crossReference
[DatabaseIdentifier:9907730] RHEA:21813
dbId
192051
displayName
CYP7A1 7-hydroxylates CHOL
edited
[InstanceEdit:193475] D'Eustachio, P, 2007年02月17日 19:40:28
eventOf
[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Homo sapiens
[Pathway:R-HSA-211976] Endogenous sterols - Homo sapiens
followingEvent
[Reaction:R-HSA-192097] 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one - Homo sapiens
input
[SimpleEntity:R-ALL-193384] CHOL [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-29364] NADPH [cytosol]
[SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:192107] Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
CYP7A1 7-hydroxylates CHOL
cholesterol + O2 + reduced (NADPH--hemoprotein reductase) => 7alpha-hydroxycholesterol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1
Cholesterol + NADPH + H+ + O2 => 7-alpha-hydroxycholesterol + NADP+ + H2O
orthologousEvent
[Reaction:R-GGA-192051] CYP7A1 7-hydroxylates CHOL - Gallus gallus
[Reaction:R-XTR-192051] CYP7A1 7-hydroxylates CHOL - Xenopus tropicalis
[Reaction:R-SSC-192051] CYP7A1 7-hydroxylates CHOL - Sus scrofa
[Reaction:R-BTA-192051] CYP7A1 7-hydroxylates CHOL - Bos taurus
[Reaction:R-CFA-192051] CYP7A1 7-hydroxylates CHOL - Canis familiaris
[Reaction:R-RNO-192051] CYP7A1 7-hydroxylates CHOL - Rattus norvegicus
[Reaction:R-MMU-192051] CYP7A1 7-hydroxylates CHOL - Mus musculus
output
[SimpleEntity:R-ALL-192114] 7 alpha-hydroxycholesterol [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent
[Reaction:R-HSA-5340195] NR1H4 binds DCA, CDCA, LCHA - Homo sapiens
regulatedBy
[NegativeRegulation:R-HSA-5340416] Negative regulation by 'NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm]'
releaseDate
2007年05月15日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:351775] D'Eustachio, P, 2008年05月28日 08:30:54
revised
[InstanceEdit:5602271] Jassal, Bijay, 2014年06月23日
[InstanceEdit:5674206] Jassal, Bijay, 2015年02月11日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-192051
summation
[Summation:192159] Cholesterol, NADPH + H+, and O2 form 7alpha-cholesterol (5-c...
updateTrackers
[UpdateTracker:9786393] Update Tracker - [Reaction:192051] CYP7A1 7-hydroxylates CHOL - v49:[addRegulator]
[UpdateTracker:9786146] Update Tracker - [Reaction:192051] CYP7A1 7-hydroxylates CHOL - v50:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9786393] Update Tracker - [Reaction:192051] CYP7A1 7-hydroxylates CHOL - v49:[addRegulator]
[UpdateTracker:9786146] Update Tracker - [Reaction:192051] CYP7A1 7-hydroxylates CHOL - v50:[modifyText]
(hasEvent)
[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
[Pathway:R-HSA-211976] Endogenous sterols
(precedingEvent)
[Reaction:R-HSA-192097] 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one
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