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Entries
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
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authored
[InstanceEdit:450323] Shamovsky, V, 2009年12月16日
compartment
[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created
[InstanceEdit:450323] Shamovsky, V, 2009年12月16日
crossReference
[DatabaseIdentifier:12757924] BioModels Database:BIOMD0000000504
[DatabaseIdentifier:12758014] BioModels Database:BIOMD0000000466
[DatabaseIdentifier:12758018] BioModels Database:BIOMD0000000468
[DatabaseIdentifier:12757928] BioModels Database:BIOMD0000000477
dbId
450321
displayName
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
edited
[InstanceEdit:532463] Shamovsky, V, 2010年02月27日
eventOf
[Pathway:R-HSA-450294] MAP kinase activation - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:20271] JNK cascade
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Homo sapiens
[Reaction:R-HSA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Homo sapiens
[Reaction:R-HSA-450348] Activated human JNKs migrate to nucleoplasm - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2018年03月26日
literatureReference
[LiteratureReference:437996] Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes
[LiteratureReference:208156] TAK1 is a ubiquitin-dependent kinase of MKK and IKK
[LiteratureReference:8979744] IL-17 mediates inflammatory reactions via p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner in human nucleus pulposus cells
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
orthologousEvent
[Pathway:R-GGA-437986] Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation - Gallus gallus
[Pathway:R-SCE-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Saccharomyces cerevisiae
[Pathway:R-SPO-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Schizosaccharomyces pombe
[Pathway:R-DDI-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Dictyostelium discoideum
[Pathway:R-CEL-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Caenorhabditis elegans
[Pathway:R-DME-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Drosophila melanogaster
[Pathway:R-GGA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Gallus gallus
[Pathway:R-XTR-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Xenopus tropicalis
[Pathway:R-DRE-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Danio rerio
[Pathway:R-SSC-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Sus scrofa
[Pathway:R-BTA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Bos taurus
[Pathway:R-CFA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Canis familiaris
[Pathway:R-RNO-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Rattus norvegicus
[Pathway:R-MMU-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Mus musculus
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:532466] Gillespie, ME, 2010年02月27日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-450321
summation
[Summation:500525] C-Jun NH2 terminal kinases (JNKs) are an evolutionarily cons...
updateTrackers
[UpdateTracker:9781872] Update Tracker - [Pathway:450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - v60:[addLiteratureReference]
[UpdateTracker:9779725] Update Tracker - [Pathway:450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - v64:[updateContainedRLE]
[UpdateTracker:9788291] Update Tracker - [Pathway:450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - v43:[modifyText, updateContainedRLE]
[UpdateTracker:9790165] Update Tracker - [Pathway:450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - v35:[modifyText, updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9781872] Update Tracker - [Pathway:450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - v60:[addLiteratureReference]
[UpdateTracker:9779725] Update Tracker - [Pathway:450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - v64:[updateContainedRLE]
[UpdateTracker:9788291] Update Tracker - [Pathway:450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - v43:[modifyText, updateContainedRLE]
[UpdateTracker:9790165] Update Tracker - [Pathway:450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - v35:[modifyText, updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-450294] MAP kinase activation
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