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Entries
Activated TAK1 phosphorylates MKK4/MKK7
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authored
[InstanceEdit:450323] Shamovsky, V, 2009年12月16日
catalystActivity
[CatalystActivity:177696] protein serine/threonine kinase activity of Activated TAK complexes [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:450323] Shamovsky, V, 2009年12月16日
dbId
450337
displayName
Activated TAK1 phosphorylates MKK4/MKK7
edited
[InstanceEdit:532463] Shamovsky, V, 2010年02月27日
eventOf
[Pathway:R-HSA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Homo sapiens
followingEvent
[Reaction:R-HSA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Homo sapiens
input
2 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[DefinedSet:R-HSA-450305] MAP2K7,MAP2K4 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:438014] Essential function for the kinase TAK1 in innate and adaptive immune responses
[LiteratureReference:438028] Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
[LiteratureReference:437996] Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
Activated TAK1 phosphorylates MKK4/MKK7
orthologousEvent
[Reaction:R-GGA-437999] Phosphorylation of MKK4 by activated TAK1 - Gallus gallus
[Reaction:R-DME-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Drosophila melanogaster
[Reaction:R-GGA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Gallus gallus
[Reaction:R-XTR-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Xenopus tropicalis
[Reaction:R-SSC-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Sus scrofa
[Reaction:R-BTA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Bos taurus
[Reaction:R-CFA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Canis familiaris
[Reaction:R-RNO-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Rattus norvegicus
[Reaction:R-MMU-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Mus musculus
output
2 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[DefinedSet:R-HSA-450299] p-MAP2K4/p-MAP2K7 [cytosol]
precedingEvent
[Reaction:R-HSA-847070] Phosphorylated TAK1 dissociates from the TLR3 receptor complex - Homo sapiens
[Reaction:R-HSA-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - Homo sapiens
[Reaction:R-HSA-936951] Activation of TAK1 complex bound to activated TLR4 complex - Homo sapiens
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:532466] Gillespie, ME, 2010年02月27日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-450337
summation
[Summation:450330] In human, phosphorylation of MKK4 (MAP2K4) and MKK7 (MAP2K7)...
updateTrackers
[UpdateTracker:9790071] Update Tracker - [Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 - v35:[modifyText]
[UpdateTracker:9788138] Update Tracker - [Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 - v43:[modifyText]
[UpdateTracker:9779901] Update Tracker - [Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 - v64:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9790071] Update Tracker - [Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 - v35:[modifyText]
[UpdateTracker:9788138] Update Tracker - [Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 - v43:[modifyText]
[UpdateTracker:9779901] Update Tracker - [Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 - v64:[modifyText]
(hasEvent)
[Pathway:R-HSA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
(precedingEvent)
[Reaction:R-HSA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7
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