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Entries
MAP kinase activation
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authored
[InstanceEdit:450362] Shamovsky, V, 2009年12月16日
compartment
[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created
[InstanceEdit:450323] Shamovsky, V, 2009年12月16日
dbId
450294
displayName
MAP kinase activation
edited
[InstanceEdit:532463] Shamovsky, V, 2010年02月27日
eventOf
[Pathway:R-HSA-448424] Interleukin-17 signaling - Homo sapiens
[Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Homo sapiens
[Pathway:R-HSA-168164] Toll Like Receptor 3 (TLR3) Cascade - Homo sapiens
[Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane - Homo sapiens
[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:172358] stress-activated MAPK cascade
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Homo sapiens
[Pathway:R-HSA-450302] activated TAK1 mediates p38 MAPK activation - Homo sapiens
[Pathway:R-HSA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Homo sapiens
[Pathway:R-HSA-450282] MAPK targets/ Nuclear events mediated by MAP kinases - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2022年06月09日
literatureReference
[LiteratureReference:500538] Mammalian MAP kinase signalling cascades
[LiteratureReference:500539] MAP kinases in the immune response
[LiteratureReference:500541] Coordinating TLR-activated signaling pathways in cells of the immune system
[LiteratureReference:500532] Selectivity of docking sites in MAPK kinases
maxDepth
5
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
MAP kinase activation
orthologousEvent
[Pathway:R-MMU-450294] MAP kinase activation - Mus musculus
[Pathway:R-RNO-450294] MAP kinase activation - Rattus norvegicus
[Pathway:R-CFA-450294] MAP kinase activation - Canis familiaris
[Pathway:R-BTA-450294] MAP kinase activation - Bos taurus
[Pathway:R-SSC-450294] MAP kinase activation - Sus scrofa
[Pathway:R-DRE-450294] MAP kinase activation - Danio rerio
[Pathway:R-XTR-450294] MAP kinase activation - Xenopus tropicalis
[Pathway:R-GGA-450294] MAP kinase activation - Gallus gallus
[Pathway:R-DME-450294] MAP kinase activation - Drosophila melanogaster
[Pathway:R-CEL-450294] MAP kinase activation - Caenorhabditis elegans
[Pathway:R-DDI-450294] MAP kinase activation - Dictyostelium discoideum
[Pathway:R-SPO-450294] MAP kinase activation - Schizosaccharomyces pombe
[Pathway:R-SCE-450294] MAP kinase activation - Saccharomyces cerevisiae
[Pathway:R-PFA-450294] MAP kinase activation - Plasmodium falciparum
[Pathway:R-GGA-451524] MAPK activation in TLR cascade - Gallus gallus
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:532466] Gillespie, ME, 2010年02月27日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-450294
summation
[Summation:500534] The mitogen activated protein kinase (MAPK) cascade, one of ...
updateTrackers
[UpdateTracker:9790401] Update Tracker - [Pathway:450294] MAP kinase activation - v33:[modifyText, updateContainedPathway]
[UpdateTracker:9787198] Update Tracker - [Pathway:450294] MAP kinase activation - v46:[updateIndirectRLE]
[UpdateTracker:9774878] Update Tracker - [Pathway:450294] MAP kinase activation - v80:[updateIndirectRLE]
[UpdateTracker:9790303] Update Tracker - [Pathway:450294] MAP kinase activation - v34:[modifyText]
[UpdateTracker:9864280] Update Tracker - [Pathway:450294] MAP kinase activation - v88:[updateIndirectRLE]
[UpdateTracker:9774734] Update Tracker - [Pathway:450294] MAP kinase activation - v81:[updateIndirectRLE]
[UpdateTracker:9782230] Update Tracker - [Pathway:450294] MAP kinase activation - v59:[updateContainedPathway]
[UpdateTracker:9790131] Update Tracker - [Pathway:450294] MAP kinase activation - v35:[modifyText, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788147] Update Tracker - [Pathway:450294] MAP kinase activation - v43:[modifyText, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9781783] Update Tracker - [Pathway:450294] MAP kinase activation - v60:[updateContainedPathway]
[UpdateTracker:9775619] Update Tracker - [Pathway:450294] MAP kinase activation - v78:[updateIndirectRLE]
[UpdateTracker:9784248] Update Tracker - [Pathway:450294] MAP kinase activation - v54:[add_removeHasEvent]
[UpdateTracker:9789076] Update Tracker - [Pathway:450294] MAP kinase activation - v38:[updateIndirectRLE]
[UpdateTracker:9784695] Update Tracker - [Pathway:450294] MAP kinase activation - v53:[add_removeHasEvent]
[UpdateTracker:9780151] Update Tracker - [Pathway:450294] MAP kinase activation - v64:[updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane
[Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling
[Pathway:R-HSA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane
[Pathway:R-HSA-168164] Toll Like Receptor 3 (TLR3) Cascade
[Pathway:R-HSA-448424] Interleukin-17 signaling
(updatedInstance)
[UpdateTracker:9790401] Update Tracker - [Pathway:450294] MAP kinase activation - v33:[modifyText, updateContainedPathway]
[UpdateTracker:9787198] Update Tracker - [Pathway:450294] MAP kinase activation - v46:[updateIndirectRLE]
[UpdateTracker:9774878] Update Tracker - [Pathway:450294] MAP kinase activation - v80:[updateIndirectRLE]
[UpdateTracker:9790303] Update Tracker - [Pathway:450294] MAP kinase activation - v34:[modifyText]
[UpdateTracker:9864280] Update Tracker - [Pathway:450294] MAP kinase activation - v88:[updateIndirectRLE]
[UpdateTracker:9774734] Update Tracker - [Pathway:450294] MAP kinase activation - v81:[updateIndirectRLE]
[UpdateTracker:9782230] Update Tracker - [Pathway:450294] MAP kinase activation - v59:[updateContainedPathway]
[UpdateTracker:9790131] Update Tracker - [Pathway:450294] MAP kinase activation - v35:[modifyText, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788147] Update Tracker - [Pathway:450294] MAP kinase activation - v43:[modifyText, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9781783] Update Tracker - [Pathway:450294] MAP kinase activation - v60:[updateContainedPathway]
[UpdateTracker:9775619] Update Tracker - [Pathway:450294] MAP kinase activation - v78:[updateIndirectRLE]
[UpdateTracker:9784248] Update Tracker - [Pathway:450294] MAP kinase activation - v54:[add_removeHasEvent]
[UpdateTracker:9789076] Update Tracker - [Pathway:450294] MAP kinase activation - v38:[updateIndirectRLE]
[UpdateTracker:9784695] Update Tracker - [Pathway:450294] MAP kinase activation - v53:[add_removeHasEvent]
[UpdateTracker:9780151] Update Tracker - [Pathway:450294] MAP kinase activation - v64:[updateIndirectRLE]
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