Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Pathway
>
Entries
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Show undefined attributes
Go to Details
authored
[InstanceEdit:166017] de Bono, B, 2005年08月16日 10:54:15
created
[InstanceEdit:166057] de Bono, B, 2005年08月16日 15:04:23
crossReference
[DatabaseIdentifier:12757928] BioModels Database:BIOMD0000000477
dbId
166058
deleted
[Deleted:9028194] Deletion of instance: 166054
diseasePathways
[Pathway:R-HSA-5602498] MyD88 deficiency (TLR2/4) - Homo sapiens
[Pathway:R-HSA-5603041] IRAK4 deficiency (TLR2/4) - Homo sapiens
displayName
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
doi
10.3180/REACT_6788.8
edited
[InstanceEdit:2562515] Shamovsky, V, 2012年11月05日
eventOf
[Pathway:R-HSA-168179] Toll Like Receptor TLR1:TLR2 Cascade - Homo sapiens
[Pathway:R-HSA-166016] Toll Like Receptor 4 (TLR4) Cascade - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:259820] MyD88-dependent toll-like receptor signaling pathway
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-2559456] TIRAP binds PIP2-rich regions in the plasma membrane - Homo sapiens
[Reaction:R-HSA-2201316] Activated TLR2/4 interacts with MAL (TIRAP) - Homo sapiens
[Reaction:R-HSA-2559414] Activated TLR2/4:TIRAP interacts with BTK - Homo sapiens
[Reaction:R-HSA-2201322] TIRAP is phosphorylated by BTK - Homo sapiens
[Reaction:R-HSA-166072] MyD88 forms a complex with TIRAP:activated TLR2/4 - Homo sapiens
[Reaction:R-HSA-937079] MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 - Homo sapiens
[Reaction:R-HSA-166082] IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex - Homo sapiens
[Reaction:R-HSA-937022] IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP - Homo sapiens
[Reaction:R-HSA-166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - Homo sapiens
[Reaction:R-HSA-937059] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex - Homo sapiens
[Reaction:R-HSA-166119] First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal - Homo sapiens
[Reaction:R-HSA-166284] Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP - Homo sapiens
[Reaction:R-HSA-166286] Multiple IRAK1 autophosphorylation steps - Homo sapiens
[Reaction:R-HSA-166363] TRAF6 binds to hp- IRAK1 - Homo sapiens
[Reaction:R-HSA-2262777] TRAF6 binds to p-IRAK2 - Homo sapiens
[Reaction:R-HSA-166362] Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex - Homo sapiens
[Reaction:R-HSA-2262775] Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex - Homo sapiens
[Pathway:R-HSA-937042] IRAK2 mediated activation of TAK1 complex - Homo sapiens
[Pathway:R-HSA-937039] IRAK1 recruits IKK complex - Homo sapiens
[Reaction:R-HSA-166869] TRAF6 binds MEKK1 - Homo sapiens
[Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation - Homo sapiens
[Pathway:R-HSA-450294] MAP kinase activation - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2022年06月09日
literatureReference
[LiteratureReference:165842] MD-2: the Toll 'gatekeeper' in endotoxin signalling
maxDepth
6
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
orthologousEvent
[Pathway:R-RNO-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Rattus norvegicus
[Pathway:R-MMU-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Mus musculus
[Pathway:R-CFA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Canis familiaris
[Pathway:R-BTA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Bos taurus
[Pathway:R-XTR-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Xenopus tropicalis
[Pathway:R-SPO-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Schizosaccharomyces pombe
[Pathway:R-GGA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Gallus gallus
[Pathway:R-DME-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Drosophila melanogaster
[Pathway:R-CEL-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Caenorhabditis elegans
[Pathway:R-SCE-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Saccharomyces cerevisiae
[Pathway:R-SSC-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Sus scrofa
[Pathway:R-DRE-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Danio rerio
[Pathway:R-DDI-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Dictyostelium discoideum
[Pathway:R-PFA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Plasmodium falciparum
relatedSpecies
[Species:181384] Chlamydia trachomatis
[Species:180800] Neisseria meningitidis serogroup B
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:188961] Gay, NJ, 2006年04月24日 16:48:17
[InstanceEdit:1095192] Gillespie, ME, 2010年11月30日
[InstanceEdit:2603254] Napetschnig, Johanna, 2012年11月16日
revised
[InstanceEdit:2558340] Shamovsky, V, 2012年11月02日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-166058
summation
[Summation:166413] The first known downstream component of TLR4 and TLR2 signal...
updateTrackers
[UpdateTracker:9788219] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v43:[addHasEvent, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9775636] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v78:[updateIndirectRLE]
[UpdateTracker:9779638] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v65:[updateIndirectRLE]
[UpdateTracker:9790410] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v33:[modifyText]
[UpdateTracker:9791883] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v25:[updateContainedRLE]
[UpdateTracker:9788750] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v40:[updateIndirectRLE]
[UpdateTracker:9784272] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v54:[updateContainedPathway]
[UpdateTracker:9782637] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v59:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9783072] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v57:[updateIndirectRLE]
[UpdateTracker:9788677] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v41:[addHasEvent, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9788422] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v42:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784729] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v53:[updateContainedPathway]
[UpdateTracker:9786381] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v49:[updateContainedRLE]
[UpdateTracker:9781944] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v60:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9789919] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v36:[updateIndirectRLE]
[UpdateTracker:9779171] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v66:[updateContainedRLE]
[UpdateTracker:9774778] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v81:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9775026] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v80:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9864321] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v88:[updateContainedRLE]
[UpdateTracker:9785361] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v52:[updateContainedPathway]
[UpdateTracker:9789309] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v38:[updateContainedPathway]
[UpdateTracker:9787540] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v44:[updateIndirectRLE]
[UpdateTracker:9789738] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v37:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9780424] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v63:[addHasEvent]
[UpdateTracker:9777846] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v68:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9776458] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v76:[updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-166016] Toll Like Receptor 4 (TLR4) Cascade
[Pathway:R-HSA-168179] Toll Like Receptor TLR1:TLR2 Cascade
[Pathway:R-HSA-168188] Toll Like Receptor TLR6:TLR2 Cascade
(hasEncapsulatedEvent)
[Pathway:R-HSA-9705683] SARS-CoV-2-host interactions
[Pathway:R-HSA-5686938] Regulation of TLR by endogenous ligand
(normalPathway)
[Pathway:R-HSA-5602498] MyD88 deficiency (TLR2/4)
[Pathway:R-HSA-5603041] IRAK4 deficiency (TLR2/4)
(replacementInstances)
[Deleted:9028194] Deletion of instance: 166054
(updatedInstance)
[UpdateTracker:9788219] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v43:[addHasEvent, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9775636] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v78:[updateIndirectRLE]
[UpdateTracker:9779638] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v65:[updateIndirectRLE]
[UpdateTracker:9790410] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v33:[modifyText]
[UpdateTracker:9791883] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v25:[updateContainedRLE]
[UpdateTracker:9788750] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v40:[updateIndirectRLE]
[UpdateTracker:9784272] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v54:[updateContainedPathway]
[UpdateTracker:9782637] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v59:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9783072] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v57:[updateIndirectRLE]
[UpdateTracker:9788677] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v41:[addHasEvent, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9788422] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v42:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784729] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v53:[updateContainedPathway]
[UpdateTracker:9786381] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v49:[updateContainedRLE]
[UpdateTracker:9781944] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v60:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9789919] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v36:[updateIndirectRLE]
[UpdateTracker:9779171] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v66:[updateContainedRLE]
[UpdateTracker:9774778] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v81:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9775026] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v80:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9864321] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v88:[updateContainedRLE]
[UpdateTracker:9785361] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v52:[updateContainedPathway]
[UpdateTracker:9789309] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v38:[updateContainedPathway]
[UpdateTracker:9787540] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v44:[updateIndirectRLE]
[UpdateTracker:9789738] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v37:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9780424] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v63:[addHasEvent]
[UpdateTracker:9777846] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v68:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9776458] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v76:[updateIndirectRLE]
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル