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Entries
IRAK1 recruits IKK complex
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authored
[InstanceEdit:847735] Shamovsky, V, 2010年06月01日
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:937009] Shamovsky, V, 2010年08月25日
crossReference
[DatabaseIdentifier:12757928] BioModels Database:BIOMD0000000477
dbId
937039
displayName
IRAK1 recruits IKK complex
edited
[InstanceEdit:2562589] Shamovsky, V, 2012年11月06日
eventOf
[Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane - Homo sapiens
[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:161528] positive regulation of canonical NF-kappaB signal transduction
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-937044] Pellino binds hp-IRAK1:TRAF6 - Homo sapiens
[Reaction:R-HSA-937034] IRAK1 phosphorylates Pellino - Homo sapiens
[Reaction:R-HSA-937050] Pellino ubiquitinates hp-IRAK1 - Homo sapiens
[Reaction:R-HSA-937032] NEMO subunit of IKK complex binds to activated IRAK1 - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2012年12月31日
literatureReference
[LiteratureReference:507721] Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3
[LiteratureReference:975459] IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation
[LiteratureReference:970055] IRAK-dependent phosphorylation of Stat1 on serine 727 in response to interleukin-1 and effects on gene expression
[LiteratureReference:507718] Interleukin-1 receptor-associated kinase (IRAK) -1-mediated NF-kappaB activation requires cytosolic and nuclear activity
[LiteratureReference:975472] Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction
[LiteratureReference:450158] Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation
[LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling
[LiteratureReference:975484] The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
IRAK1 recruits IKK complex
orthologousEvent
[Pathway:R-DME-937039] IRAK1 recruits IKK complex - Drosophila melanogaster
[Pathway:R-SSC-937039] IRAK1 recruits IKK complex - Sus scrofa
[Pathway:R-BTA-937039] IRAK1 recruits IKK complex - Bos taurus
[Pathway:R-CFA-937039] IRAK1 recruits IKK complex - Canis familiaris
[Pathway:R-RNO-937039] IRAK1 recruits IKK complex - Rattus norvegicus
[Pathway:R-MMU-937039] IRAK1 recruits IKK complex - Mus musculus
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1095192] Gillespie, ME, 2010年11月30日
[InstanceEdit:2603254] Napetschnig, Johanna, 2012年11月16日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-937039
summation
[Summation:970054] The role of IRAK1 kinase activity in the activation of NF-ka...
updateTrackers
[UpdateTracker:9789294] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v38:[addLiteratureReference, modifyText]
[UpdateTracker:9788182] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v43:[modifyText, updateContainedRLE]
[UpdateTracker:9789678] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v37:[updateContainedRLE]
[UpdateTracker:9788439] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v42:[modifyText, updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9789294] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v38:[addLiteratureReference, modifyText]
[UpdateTracker:9788182] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v43:[modifyText, updateContainedRLE]
[UpdateTracker:9789678] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v37:[updateContainedRLE]
[UpdateTracker:9788439] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v42:[modifyText, updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane
[Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane
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