Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
Show undefined attributes
Go to Details
authored
[InstanceEdit:166017] de Bono, B, 2005年08月16日 10:54:15
category
binding
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:166092] de Bono, B, 2005年08月17日 10:27:50
dbId
166091
displayName
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
edited
[InstanceEdit:2562589] Shamovsky, V, 2012年11月06日
eventOf
[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens
followingEvent
[Reaction:R-HSA-937059] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex - Homo sapiens
[Reaction:R-HSA-166119] First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal - Homo sapiens
input
4 ×
[DefinedSet:R-HSA-937023] IRAK1, IRAK2 [cytosol]
[Complex:R-HSA-937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:165888] A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in toll/IL-1R-induced inflammatory
[LiteratureReference:450126] IRAK1: a critical signaling mediator of innate immunity
[LiteratureReference:450125] IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination
[LiteratureReference:570877] Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control
[LiteratureReference:2428843] Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha
[LiteratureReference:937049] Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
orthologousEvent
[Reaction:R-GGA-433864] IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88 - Gallus gallus
output
[Complex:R-HSA-166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane]
precedingEvent
[Reaction:R-HSA-937022] IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP - Homo sapiens
relatedSpecies
[Species:180800] Neisseria meningitidis serogroup B
[Species:181384] Chlamydia trachomatis
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:188961] Gay, NJ, 2006年04月24日 16:48:17
[InstanceEdit:1095192] Gillespie, ME, 2010年11月30日
[InstanceEdit:2603254] Napetschnig, Johanna, 2012年11月16日
revised
[InstanceEdit:937065] Shamovsky, V, 2010年08月25日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-166091
summation
[Summation:2586631] IRAK1 is recruited to the TLR complex through binding with I...
[Summation:446680] IRAK2 has been implicated in IL1R and TLR signaling by the o...
updateTrackers
[UpdateTracker:9782066] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v59:[modifyText]
[UpdateTracker:9789735] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v37:[modifyText]
[UpdateTracker:9788381] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v42:[addLiteratureReference]
[UpdateTracker:9788128] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v43:[addLiteratureReference, add_removeSummation]
Referrals
(updatedInstance)
[UpdateTracker:9782066] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v59:[modifyText]
[UpdateTracker:9789735] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v37:[modifyText]
[UpdateTracker:9788381] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v42:[addLiteratureReference]
[UpdateTracker:9788128] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v43:[addLiteratureReference, add_removeSummation]
(precedingEvent)
[Reaction:R-HSA-937059] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex
[Reaction:R-HSA-166119] First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
(hasEvent)
[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル