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Schema
>
Complex
>
Entries
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane]
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compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:166099] de Bono, B, 2005年08月17日 10:44:00
dbId
166100
displayName
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane]
hasComponent
4 ×
[DefinedSet:R-HSA-937026] IRAK1/ IRAK2 [plasma membrane]
[Complex:R-HSA-937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane]
inDisease
false
includedLocation
[Compartment:70101] cytosol
inferredTo
[Complex:R-GGA-434002] IRAK2 : p-IRAK4 :MyD88 : TIRAP : activated TLR [plasma membrane] - Gallus gallus
[Complex:R-GGA-977244] IRAK2 : p-IRAK4 :MyD88 : activated TLR [plasma membrane] - Gallus gallus
literatureReference
[LiteratureReference:937049] Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
[LiteratureReference:571295] Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases
[LiteratureReference:2428888] Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
[LiteratureReference:2428820] IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)
maxDepth
10
modified
[InstanceEdit:9615894] Shamovsky, Veronica, 2018年08月09日
name
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:Mal:activated TLR
producedByEvent
[Reaction:R-HSA-166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - Homo sapiens
relatedSpecies
[Species:181384] Chlamydia trachomatis
[Species:180800] Neisseria meningitidis serogroup B
schemaClass
Complex
species
[Species:48887] Homo sapiens
stId
R-HSA-166100
updateTrackers
[UpdateTracker:9867519] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v25:[updateContainedComponent]
[UpdateTracker:9868745] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v32:[updateContainedComponent]
[UpdateTracker:9899608] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v66:[addName, updateContainedComponent]
[UpdateTracker:9874058] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v43:[updateContainedComponent]
[UpdateTracker:9899779] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v67:[updateContainedComponent]
[UpdateTracker:9868462] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v31:[updateContainedComponent]
[UpdateTracker:9870223] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v38:[updateContainedComponent]
[UpdateTracker:9870983] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v39:[updateContainedComponent]
[UpdateTracker:9901950] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v76:[updateContainedComponent]
[UpdateTracker:9895780] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v59:[updateContainedComponent]
[UpdateTracker:9890571] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v52:[updateContainedComponent]
[UpdateTracker:9892932] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v54:[updateContainedComponent]
[UpdateTracker:9896454] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v60:[removeSpecies, updateContainedComponent]
[UpdateTracker:9863788] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v20:[updateContainedComponent]
[UpdateTracker:9873203] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9889381] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v49:[updateContainedComponent]
[UpdateTracker:9872001] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v41:[updateContainedComponent]
Referrals
(updatedInstance)
[UpdateTracker:9867519] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v25:[updateContainedComponent]
[UpdateTracker:9868745] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v32:[updateContainedComponent]
[UpdateTracker:9899608] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v66:[addName, updateContainedComponent]
[UpdateTracker:9874058] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v43:[updateContainedComponent]
[UpdateTracker:9899779] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v67:[updateContainedComponent]
[UpdateTracker:9868462] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v31:[updateContainedComponent]
[UpdateTracker:9870223] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v38:[updateContainedComponent]
[UpdateTracker:9870983] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v39:[updateContainedComponent]
[UpdateTracker:9901950] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v76:[updateContainedComponent]
[UpdateTracker:9895780] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v59:[updateContainedComponent]
[UpdateTracker:9890571] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v52:[updateContainedComponent]
[UpdateTracker:9892932] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v54:[updateContainedComponent]
[UpdateTracker:9896454] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v60:[removeSpecies, updateContainedComponent]
[UpdateTracker:9863788] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v20:[updateContainedComponent]
[UpdateTracker:9873203] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9889381] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v49:[updateContainedComponent]
[UpdateTracker:9872001] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v41:[updateContainedComponent]
(output)
[Reaction:R-HSA-166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
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