Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88
Show undefined attributes
Go to Details
authored
[InstanceEdit:434153] Shamovsky, V, 2009年08月26日
category
binding
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:434122] Shamovsky, V, 2009年08月26日
dbId
433864
displayName
IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88
edited
[InstanceEdit:994006] Shamovsky, V, 2010年11月05日
eventOf
[Pathway:R-GGA-451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane - Gallus gallus
followingEvent
[Reaction:R-GGA-434047] phosphorylation of IRAK2 by activated IRAK4 - Gallus gallus
inferredFrom
[Reaction:R-HSA-166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - Homo sapiens
input
[Complex:R-GGA-434022] activated TLR : TIRAP : MyD88 ; p-IRAK4 [plasma membrane]
2 ×
[EntityWithAccessionedSequence:R-GGA-434068] IRAK2 [cytosol]
isInDisease
false
isInferred
true
literatureReference
[LiteratureReference:434579] The avian Toll-Like receptor pathway--subtle differences amidst general conformity
[LiteratureReference:446698] Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88
output
[Complex:R-GGA-434002] IRAK2 : p-IRAK4 :MyD88 : TIRAP : activated TLR [plasma membrane]
precedingEvent
[Reaction:R-GGA-434018] Autophosphorylation of chicken IRAK4 - Gallus gallus
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:977269] D'Eustachio, P, 2010年10月15日
schemaClass
Reaction
species
[Species:49591] Gallus gallus
stId
R-GGA-433864
summation
[Summation:570878] In mammals activated IRAK4 phosphorylates both IRAK1 and IRA...
updateTrackers
[UpdateTracker:9789925] Update Tracker - [Reaction:433864] IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88 - v36:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9789925] Update Tracker - [Reaction:433864] IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88 - v36:[modifyText]
(hasEvent)
[Pathway:R-GGA-451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane
(precedingEvent)
[Reaction:R-GGA-434047] phosphorylation of IRAK2 by activated IRAK4
(inferredTo)
[Reaction:R-HSA-166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル