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Entries
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation
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authored
[InstanceEdit:438031] Shamovsky, V, 2009年09月22日
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:438021] Shamovsky, V, 2009年09月22日
dbId
437986
displayName
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation
edited
[InstanceEdit:1217489] Shamovsky, V, 2011年02月17日
eventOf
[Pathway:R-GGA-451524] MAPK activation in TLR cascade - Gallus gallus
goBiologicalProcess
[GO_BiologicalProcess:20271] JNK cascade
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-GGA-437999] Phosphorylation of MKK4 by activated TAK1 - Gallus gallus
[Reaction:R-GGA-438005] MKK4 phosphorylates JNK - Gallus gallus
[Reaction:R-GGA-437995] Activated JNK migrates to the nucleoplasm - Gallus gallus
[Reaction:R-GGA-438026] Activation and dimerization of c-JUN in the nucleus - Gallus gallus
inferredFrom
[Pathway:R-HSA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Homo sapiens
isInDisease
false
isInferred
true
literatureReference
[LiteratureReference:169962] Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo.
[LiteratureReference:438014] Essential function for the kinase TAK1 in innate and adaptive immune responses
[LiteratureReference:438028] Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
[LiteratureReference:437996] Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes
[LiteratureReference:208156] TAK1 is a ubiquitin-dependent kinase of MKK and IKK
[LiteratureReference:208252] Signal transduction by the JNK group of MAP kinases
[LiteratureReference:437954] Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
[LiteratureReference:442954] Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
maxDepth
2
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:789693] D'Eustachio, P, 2010年05月23日
schemaClass
Pathway
species
[Species:49591] Gallus gallus
stId
R-GGA-437986
summation
[Summation:446240] C-Jun NH2 terminal kinases are stress activated MAPKs, also ...
Referrals
(hasEvent)
[Pathway:R-GGA-451524] MAPK activation in TLR cascade
(inferredTo)
[Pathway:R-HSA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
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