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Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
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authored
[InstanceEdit:749521] Dall'Olio, GM, 2009年11月10日
created
[InstanceEdit:446206] Jassal, B, 2009年11月10日
dbId
446193
displayName
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
edited
[InstanceEdit:446206] Jassal, B, 2009年11月10日
eventOf
[Pathway:R-HSA-446203] Asparagine N-linked glycosylation - Homo sapiens
figure
[Figure:686119] /figures/Glycobiology_reduced.jpg
goBiologicalProcess
[GO_BiologicalProcess:18691] dolichol-linked oligosaccharide biosynthetic process
hasDiagram
false
hasEHLD
false
hasEvent
[Pathway:R-HSA-446219] Synthesis of substrates in N-glycan biosythesis - Homo sapiens
[Reaction:R-HSA-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Homo sapiens
[Reaction:R-HSA-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Homo sapiens
[Reaction:R-HSA-446218] Addition of the first mannose to the N-glycan precursor by ALG1 - Homo sapiens
[Reaction:R-HSA-446208] Addition of a second mannose to the N-glycan precursor by ALG2 - Homo sapiens
[Reaction:R-HSA-449718] Addition of a third mannose to the N-glycan precursor by ALG2 - Homo sapiens
[Reaction:R-HSA-446187] ALG11 transfers the fourth and fifth Man to the N-glycan precursor - Homo sapiens
[Reaction:R-HSA-446212] Flipping of the N-glycan precursor to inside the ER - Homo sapiens
[Reaction:R-HSA-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Homo sapiens
[Reaction:R-HSA-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Homo sapiens
[Reaction:R-HSA-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Homo sapiens
[Reaction:R-HSA-446216] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 - Homo sapiens
[Reaction:R-HSA-446202] Addition of the first glucose to the N-glycan precursor by ALG6 - Homo sapiens
[Reaction:R-HSA-446189] Addition of a second glucose to the N-glycan precursor by ALG8 - Homo sapiens
[Reaction:R-HSA-446194] Addition of a third glucose to the N-glycan precursor by an ALG10 homologue - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2019年03月25日
literatureReference
[Book:771699] Congenital Disorders of Glycosylation Overview
maxDepth
4
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
orthologousEvent
[Pathway:R-SSC-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Sus scrofa
[Pathway:R-GGA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Gallus gallus
[Pathway:R-DME-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Drosophila melanogaster
[Pathway:R-CEL-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Caenorhabditis elegans
[Pathway:R-CFA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Canis familiaris
[Pathway:R-BTA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Bos taurus
[Pathway:R-XTR-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Xenopus tropicalis
[Pathway:R-SCE-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Saccharomyces cerevisiae
[Pathway:R-SPO-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Schizosaccharomyces pombe
[Pathway:R-RNO-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Rattus norvegicus
[Pathway:R-DDI-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Dictyostelium discoideum
[Pathway:R-MMU-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Mus musculus
[Pathway:R-DRE-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Danio rerio
[Pathway:R-PFA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Plasmodium falciparum
releaseDate
2010年06月15日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:749519] Gagneux, P, 2010年04月16日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-446193
summation
[Summation:449250] N-linked glycosylation commences with the 14-step synthesis ...
updateTrackers
[UpdateTracker:9783363] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v56:[updateContainedPathway]
[UpdateTracker:9778519] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v68:[updateContainedPathway]
[UpdateTracker:9790283] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v34:[modifyText, updateContainedPathway, updateContainedRLE]
[UpdateTracker:9787240] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v46:[modifyText, updateContainedPathway]
[UpdateTracker:9789702] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v37:[updateContainedRLE]
[UpdateTracker:9783947] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v55:[updateContainedPathway]
[UpdateTracker:9782073] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v59:[updateContainedRLE]
[UpdateTracker:9785757] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v51:[updateContainedRLE]
[UpdateTracker:9786789] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v48:[updateContainedPathway]
[UpdateTracker:9910987] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v89:[updateContainedPathway]
[UpdateTracker:9786880] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v47:[updateContainedPathway, updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-446203] Asparagine N-linked glycosylation
(updatedInstance)
[UpdateTracker:9783363] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v56:[updateContainedPathway]
[UpdateTracker:9778519] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v68:[updateContainedPathway]
[UpdateTracker:9790283] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v34:[modifyText, updateContainedPathway, updateContainedRLE]
[UpdateTracker:9787240] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v46:[modifyText, updateContainedPathway]
[UpdateTracker:9789702] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v37:[updateContainedRLE]
[UpdateTracker:9783947] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v55:[updateContainedPathway]
[UpdateTracker:9782073] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v59:[updateContainedRLE]
[UpdateTracker:9785757] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v51:[updateContainedRLE]
[UpdateTracker:9786789] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v48:[updateContainedPathway]
[UpdateTracker:9910987] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v89:[updateContainedPathway]
[UpdateTracker:9786880] Update Tracker - [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - v47:[updateContainedPathway, updateContainedRLE]
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