Reactome Pathway Database

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ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 Show undefined attributes

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authored

[InstanceEdit:749521] Dall'Olio, GM, 2009年11月10日

catalystActivity

[CatalystActivity:449367] mannosyltransferase activity of ALG12 [endoplasmic reticulum membrane]

category transition

compartment

[Compartment:17957] endoplasmic reticulum lumen

created [InstanceEdit:446206] Jassal, B, 2009年11月10日

dbId 446198

displayName ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1

edited

[InstanceEdit:446206] Jassal, B, 2009年11月10日

eventOf

[Pathway:R-HSA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Homo sapiens

figure

[Figure:975566] /figures/11_GlcNAc2Man8PPDol.png

followingEvent

[Reaction:R-HSA-446216] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 - Homo sapiens

input

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:449352] Congenital disorders of glycosylation type Ig is defined by a deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase

maxDepth 1

modified [InstanceEdit:11033291] Weiser, Joel, 2025年08月28日

name

ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1
Addition of the eighth mannose to the N-glycan precursor by ALG12

orthologousEvent

output

precedingEvent

[Reaction:R-HSA-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Homo sapiens

regulatedBy

[PositiveRegulation:R-HSA-4628426] Positive regulation by 'MPDU1 [endoplasmic reticulum membrane]'

releaseDate 2010年06月15日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:749519] Gagneux, P, 2010年04月16日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-446198

summation

[Summation:449364] The eighth mannose is added to the N-glycan precursor. This ...

updateTrackers

Referrals

(updatedInstance)

(normalReaction)

(hasEvent)

[Pathway:R-HSA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

(precedingEvent)

[Reaction:R-HSA-446216] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1

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