Reactome Pathway Database

Schema > Reaction > Entries

ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 Show undefined attributes

catalystActivity

[CatalystActivity:10233009] mannosyltransferase activity of ALG12 [endoplasmic reticulum membrane]

category transition

compartment

[Compartment:17957] endoplasmic reticulum lumen

created [InstanceEdit:10201029] Weiser, Joel, 2025年08月27日

dbId 10233011

displayName ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1

eventOf

[Pathway:R-CFA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Canis familiaris

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-CFA-446216] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 - Canis familiaris

inferredFrom

[Reaction:R-HSA-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1
Addition of the eighth mannose to the N-glycan precursor by ALG12

output

precedingEvent

[Reaction:R-CFA-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Canis familiaris

regulatedBy

[PositiveRegulation:10232983] Positive regulation by 'MPDU1 [endoplasmic reticulum membrane]'

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49646] Canis familiaris

stId R-CFA-446198

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-CFA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

(precedingEvent)

[Reaction:R-CFA-446216] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1

(inferredTo)

[Reaction:R-HSA-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1

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