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Sialic acid metabolism
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authored
[InstanceEdit:4085031] Jassal, Bijay, 2013年08月01日
created
[InstanceEdit:4085031] Jassal, Bijay, 2013年08月01日
dbId
4085001
diseasePathways
[Pathway:R-HSA-4085011] Defective GNE causes sialuria, NK and IBM2 - Homo sapiens
[Pathway:R-HSA-4341670] Defective NEU1 causes sialidosis - Homo sapiens
[Pathway:R-HSA-5619035] Defective SLC17A5 causes Salla disease (SD) and ISSD - Homo sapiens
[Pathway:R-HSA-5663020] Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) - Homo sapiens
displayName
Sialic acid metabolism
doi
10.3180/REACT_200874.1
edited
[InstanceEdit:4085031] Jassal, Bijay, 2013年08月01日
eventOf
[Pathway:R-HSA-446219] Synthesis of substrates in N-glycan biosythesis - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-4085021] GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP - Homo sapiens
[Reaction:R-HSA-4085028] GNE phosphorylates ManNAc to ManNAc-6-P - Homo sapiens
[Reaction:R-HSA-4084976] NANS converts ManNAc-6-P to Neu5Ac-9-P - Homo sapiens
[Reaction:R-HSA-4084989] NANP dephosphorylates Neu5Ac-9-P to Neu5Ac - Homo sapiens
[BlackBoxEvent:R-HSA-4085020] Cytosolic Neu5Ac translocates to nucleus - Homo sapiens
[Reaction:R-HSA-4084982] CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac - Homo sapiens
[BlackBoxEvent:R-HSA-4084990] Nuclear CMP-Neu5Ac translocates to cytosol - Homo sapiens
[Reaction:R-HSA-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Homo sapiens
[Reaction:R-HSA-4084984] ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) - Homo sapiens
[Reaction:R-HSA-4085033] ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) - Homo sapiens
[Reaction:R-HSA-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Homo sapiens
[Reaction:R-HSA-4084978] ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues - Homo sapiens
[BlackBoxEvent:R-HSA-4088207] Golgi lumen glycoconjugates translocate to the plasma membrane - Homo sapiens
[Reaction:R-HSA-4084994] NEU3 hydrolyzes Neu5Ac from glycoconjugates - Homo sapiens
[BlackBoxEvent:R-HSA-4088210] Cytosolic glycoconjugates translocate to the lysosome - Homo sapiens
[Reaction:R-HSA-4084999] NEU1 hydrolyses Neu5Ac from glycoconjugates - Homo sapiens
[Reaction:R-HSA-9638120] NEU4 hydrolyses Neu5Ac from glycoconjugates - Homo sapiens
[BlackBoxEvent:R-HSA-4088205] Plasma membrane glycoconjugates translocate to the cytosol - Homo sapiens
[Reaction:R-HSA-4085029] NEU2 hydrolyzes Neu5Ac from glycoconjugates - Homo sapiens
[Reaction:R-HSA-428585] SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol - Homo sapiens
[Reaction:R-HSA-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2019年03月25日
literatureReference
[LiteratureReference:4088193] Sialic acid metabolism and sialyltransferases: natural functions and applications
[LiteratureReference:4088195] Primer on genes encoding enzymes in sialic acid metabolism in mammals
maxDepth
2
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Sialic acid metabolism
orthologousEvent
[Pathway:R-MMU-4085001] Sialic acid metabolism - Mus musculus
[Pathway:R-CFA-4085001] Sialic acid metabolism - Canis familiaris
[Pathway:R-BTA-4085001] Sialic acid metabolism - Bos taurus
[Pathway:R-SSC-4085001] Sialic acid metabolism - Sus scrofa
[Pathway:R-DRE-4085001] Sialic acid metabolism - Danio rerio
[Pathway:R-XTR-4085001] Sialic acid metabolism - Xenopus tropicalis
[Pathway:R-GGA-4085001] Sialic acid metabolism - Gallus gallus
[Pathway:R-DME-4085001] Sialic acid metabolism - Drosophila melanogaster
[Pathway:R-CEL-4085001] Sialic acid metabolism - Caenorhabditis elegans
[Pathway:R-PFA-4085001] Sialic acid metabolism - Plasmodium falciparum
[Pathway:R-RNO-4085001] Sialic acid metabolism - Rattus norvegicus
[Pathway:R-DDI-4085001] Sialic acid metabolism - Dictyostelium discoideum
releaseDate
2014年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5225590] Medrano, Juan F, Wickramasinghe, Saumya, 2014年01月08日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-4085001
summation
[Summation:4088194] Sialic acids are a family of 9 carbon alpha-keto acids that ...
updateTrackers
[UpdateTracker:9785031] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v52:[updateContainedRLE]
[UpdateTracker:9785568] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v51:[updateContainedRLE]
[UpdateTracker:9778466] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v68:[addHasEvent, updateContainedRLE]
[UpdateTracker:9784697] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v53:[updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-446219] Synthesis of substrates in N-glycan biosythesis
(hasEncapsulatedEvent)
[Pathway:R-HSA-428157] Sphingolipid metabolism
(normalPathway)
[Pathway:R-HSA-4085011] Defective GNE causes sialuria, NK and IBM2
[Pathway:R-HSA-4341670] Defective NEU1 causes sialidosis
[Pathway:R-HSA-5619035] Defective SLC17A5 causes Salla disease (SD) and ISSD
[Pathway:R-HSA-5663020] Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)
(updatedInstance)
[UpdateTracker:9785031] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v52:[updateContainedRLE]
[UpdateTracker:9785568] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v51:[updateContainedRLE]
[UpdateTracker:9778466] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v68:[addHasEvent, updateContainedRLE]
[UpdateTracker:9784697] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v53:[updateContainedRLE]
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